Abnormal connectivity in the posterior cingulate and hippocampus in early Alzheimer's disease and mild cognitive impairment

Yongxia Zhou, John Dougherty, Karl Hubner, Bing Bai, Rex L. Cannon, R. Kent Hutson

Research output: Contribution to journalArticle

185 Citations (Scopus)

Abstract

Background: Brain imaging studies of early Alzheimer's disease (AD) have shown decreased metabolism predominantly in the posterior cingulate cortex (PCC), medial temporal lobe, and inferior parietal lobe. This study investigated functional connectivity between these regions, as well as connectivity between these regions and the whole brain. Methods: Functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) studies were performed in subjects with early AD, mild cognitive impairment (MCI), and normal controls. Results: The data indicate both decreased fiber connections and disrupted connectivity between the hippocampus and PCC in early AD. The MCI group showed reduced fiber numbers derived from PCC and hippocampus to the whole brain. Conclusions: The fMRI and DTI results confirmed decreased connectivity from both the PCC and hippocampus to the whole brain in MCI and AD and reduction in connectivity between these two regions, which plausibly represents an early imaging biomarker for AD.

Original languageEnglish (US)
Pages (from-to)265-270
Number of pages6
JournalAlzheimer's and Dementia
Volume4
Issue number4
DOIs
StatePublished - Jul 1 2008

Fingerprint

Gyrus Cinguli
Hippocampus
Alzheimer Disease
Diffusion Tensor Imaging
Brain
Magnetic Resonance Imaging
Parietal Lobe
Temporal Lobe
Neuroimaging
Biomarkers
Cognitive Dysfunction

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Abnormal connectivity in the posterior cingulate and hippocampus in early Alzheimer's disease and mild cognitive impairment. / Zhou, Yongxia; Dougherty, John; Hubner, Karl; Bai, Bing; Cannon, Rex L.; Hutson, R. Kent.

In: Alzheimer's and Dementia, Vol. 4, No. 4, 01.07.2008, p. 265-270.

Research output: Contribution to journalArticle

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