Abnormal resting state corticolimbic blood flow in depressed unmedicated patients with major depression

A 15O-H 2O PET study

E. Serap Monkul, Leandro A.P. Silva, Shalini Narayana, Marco A.M. Peluso, Frank Zamarripa, Fabiano G. Nery, Pablo Najt, John Li, Jack L. Lancaster, Peter T. Fox, Beny Lafer, Jair C. Soares

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

We investigated the differences in the resting state corticolimbic blood flow between 20 unmedicated depressed patients and 21 healthy comparisons. Resting state cerebral blood flow (CBF) was measured with H 2 15O PET. Anatomical MRI scans were performed on an Elscint 1.9 T Prestige system for PET-MRI coregistration. Significant changes in cerebral blood flow indicating neural activity were detected using an ROI-free image subtraction strategy. In addition, the resting blood flow in patients was correlated with the severity of depression as measured by HAM-D scores. Depressed patients showed decreases in blood flow in right anterior cingulate (Brodmann areas 24 and 32) and increased blood flow in left and right posterior cingulate (Brodmann areas 23, 29, 30), left parahippocampal gyrus (Brodmann area 36), and right caudate compared with healthy volunteers. The severity of depression was inversely correlated with the left middle and inferior frontal gyri (Brodmann areas 9 and 47) and right medial frontal gyrus (Brodmann area 10) and right anterior cingulate (Brodmann areas 24, 32) blood flow, and directly correlated with the right thalamus blood flow. These findings support previous reports of abnormalities in the resting state blood flow in the limbic-frontal structures in depressed patients compared to healthy volunteers.

Original languageEnglish (US)
Pages (from-to)272-279
Number of pages8
JournalHuman Brain Mapping
Volume33
Issue number2
DOIs
StatePublished - Feb 1 2012
Externally publishedYes

Fingerprint

Gyrus Cinguli
Cerebrovascular Circulation
Prefrontal Cortex
Healthy Volunteers
Parahippocampal Gyrus
Thalamus
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Abnormal resting state corticolimbic blood flow in depressed unmedicated patients with major depression : A 15O-H 2O PET study. / Monkul, E. Serap; Silva, Leandro A.P.; Narayana, Shalini; Peluso, Marco A.M.; Zamarripa, Frank; Nery, Fabiano G.; Najt, Pablo; Li, John; Lancaster, Jack L.; Fox, Peter T.; Lafer, Beny; Soares, Jair C.

In: Human Brain Mapping, Vol. 33, No. 2, 01.02.2012, p. 272-279.

Research output: Contribution to journalArticle

Monkul, ES, Silva, LAP, Narayana, S, Peluso, MAM, Zamarripa, F, Nery, FG, Najt, P, Li, J, Lancaster, JL, Fox, PT, Lafer, B & Soares, JC 2012, 'Abnormal resting state corticolimbic blood flow in depressed unmedicated patients with major depression: A 15O-H 2O PET study', Human Brain Mapping, vol. 33, no. 2, pp. 272-279. https://doi.org/10.1002/hbm.21212
Monkul, E. Serap ; Silva, Leandro A.P. ; Narayana, Shalini ; Peluso, Marco A.M. ; Zamarripa, Frank ; Nery, Fabiano G. ; Najt, Pablo ; Li, John ; Lancaster, Jack L. ; Fox, Peter T. ; Lafer, Beny ; Soares, Jair C. / Abnormal resting state corticolimbic blood flow in depressed unmedicated patients with major depression : A 15O-H 2O PET study. In: Human Brain Mapping. 2012 ; Vol. 33, No. 2. pp. 272-279.
@article{1846c56047ff4cc4b39ffab4a5190d7b,
title = "Abnormal resting state corticolimbic blood flow in depressed unmedicated patients with major depression: A 15O-H 2O PET study",
abstract = "We investigated the differences in the resting state corticolimbic blood flow between 20 unmedicated depressed patients and 21 healthy comparisons. Resting state cerebral blood flow (CBF) was measured with H 2 15O PET. Anatomical MRI scans were performed on an Elscint 1.9 T Prestige system for PET-MRI coregistration. Significant changes in cerebral blood flow indicating neural activity were detected using an ROI-free image subtraction strategy. In addition, the resting blood flow in patients was correlated with the severity of depression as measured by HAM-D scores. Depressed patients showed decreases in blood flow in right anterior cingulate (Brodmann areas 24 and 32) and increased blood flow in left and right posterior cingulate (Brodmann areas 23, 29, 30), left parahippocampal gyrus (Brodmann area 36), and right caudate compared with healthy volunteers. The severity of depression was inversely correlated with the left middle and inferior frontal gyri (Brodmann areas 9 and 47) and right medial frontal gyrus (Brodmann area 10) and right anterior cingulate (Brodmann areas 24, 32) blood flow, and directly correlated with the right thalamus blood flow. These findings support previous reports of abnormalities in the resting state blood flow in the limbic-frontal structures in depressed patients compared to healthy volunteers.",
author = "Monkul, {E. Serap} and Silva, {Leandro A.P.} and Shalini Narayana and Peluso, {Marco A.M.} and Frank Zamarripa and Nery, {Fabiano G.} and Pablo Najt and John Li and Lancaster, {Jack L.} and Fox, {Peter T.} and Beny Lafer and Soares, {Jair C.}",
year = "2012",
month = "2",
day = "1",
doi = "10.1002/hbm.21212",
language = "English (US)",
volume = "33",
pages = "272--279",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Abnormal resting state corticolimbic blood flow in depressed unmedicated patients with major depression

T2 - A 15O-H 2O PET study

AU - Monkul, E. Serap

AU - Silva, Leandro A.P.

AU - Narayana, Shalini

AU - Peluso, Marco A.M.

AU - Zamarripa, Frank

AU - Nery, Fabiano G.

AU - Najt, Pablo

AU - Li, John

AU - Lancaster, Jack L.

AU - Fox, Peter T.

AU - Lafer, Beny

AU - Soares, Jair C.

PY - 2012/2/1

Y1 - 2012/2/1

N2 - We investigated the differences in the resting state corticolimbic blood flow between 20 unmedicated depressed patients and 21 healthy comparisons. Resting state cerebral blood flow (CBF) was measured with H 2 15O PET. Anatomical MRI scans were performed on an Elscint 1.9 T Prestige system for PET-MRI coregistration. Significant changes in cerebral blood flow indicating neural activity were detected using an ROI-free image subtraction strategy. In addition, the resting blood flow in patients was correlated with the severity of depression as measured by HAM-D scores. Depressed patients showed decreases in blood flow in right anterior cingulate (Brodmann areas 24 and 32) and increased blood flow in left and right posterior cingulate (Brodmann areas 23, 29, 30), left parahippocampal gyrus (Brodmann area 36), and right caudate compared with healthy volunteers. The severity of depression was inversely correlated with the left middle and inferior frontal gyri (Brodmann areas 9 and 47) and right medial frontal gyrus (Brodmann area 10) and right anterior cingulate (Brodmann areas 24, 32) blood flow, and directly correlated with the right thalamus blood flow. These findings support previous reports of abnormalities in the resting state blood flow in the limbic-frontal structures in depressed patients compared to healthy volunteers.

AB - We investigated the differences in the resting state corticolimbic blood flow between 20 unmedicated depressed patients and 21 healthy comparisons. Resting state cerebral blood flow (CBF) was measured with H 2 15O PET. Anatomical MRI scans were performed on an Elscint 1.9 T Prestige system for PET-MRI coregistration. Significant changes in cerebral blood flow indicating neural activity were detected using an ROI-free image subtraction strategy. In addition, the resting blood flow in patients was correlated with the severity of depression as measured by HAM-D scores. Depressed patients showed decreases in blood flow in right anterior cingulate (Brodmann areas 24 and 32) and increased blood flow in left and right posterior cingulate (Brodmann areas 23, 29, 30), left parahippocampal gyrus (Brodmann area 36), and right caudate compared with healthy volunteers. The severity of depression was inversely correlated with the left middle and inferior frontal gyri (Brodmann areas 9 and 47) and right medial frontal gyrus (Brodmann area 10) and right anterior cingulate (Brodmann areas 24, 32) blood flow, and directly correlated with the right thalamus blood flow. These findings support previous reports of abnormalities in the resting state blood flow in the limbic-frontal structures in depressed patients compared to healthy volunteers.

UR - http://www.scopus.com/inward/record.url?scp=84862907618&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862907618&partnerID=8YFLogxK

U2 - 10.1002/hbm.21212

DO - 10.1002/hbm.21212

M3 - Article

VL - 33

SP - 272

EP - 279

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 2

ER -