Absence of group II phospholipase A2, a Paneth cell marker, from the epididymis

Timo J. Nevalainen, Varsha I. Shah, Mariza De PeraltaVenturina, Mahul Amin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Paneth cell-like metaplasia has been reported in the epithelium of the epididymis and prostatic adenocarcinomas. We studied the expression of group II phospholipase A2 (PLA2), a marker of Paneth cell differentiation, in six orchiectomy specimens with Paneth cell-like metaplasia. Both immunohistochemistry for group II PLA2 protein and in situ hybridization for the mRNA of group II PLA2 gave negative results in all six cases but positive reaction for lysozyme. The results show that the cells of the Paneth cell-like metaplasia are not true Paneth cells.

Original languageEnglish (US)
Pages (from-to)295-298
Number of pages4
JournalAPMIS
Volume109
Issue number4
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint

Group II Phospholipases A2
Paneth Cells
Epididymis
Metaplasia
Orchiectomy
Muramidase
In Situ Hybridization
Cell Differentiation
Adenocarcinoma
Epithelium
Immunohistochemistry
Messenger RNA
Proteins

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Immunology and Allergy
  • Microbiology (medical)

Cite this

Absence of group II phospholipase A2, a Paneth cell marker, from the epididymis. / Nevalainen, Timo J.; Shah, Varsha I.; De PeraltaVenturina, Mariza; Amin, Mahul.

In: APMIS, Vol. 109, No. 4, 01.01.2001, p. 295-298.

Research output: Contribution to journalArticle

Nevalainen, Timo J. ; Shah, Varsha I. ; De PeraltaVenturina, Mariza ; Amin, Mahul. / Absence of group II phospholipase A2, a Paneth cell marker, from the epididymis. In: APMIS. 2001 ; Vol. 109, No. 4. pp. 295-298.
@article{6d36e9f83ae544a6884b5acc1cca9369,
title = "Absence of group II phospholipase A2, a Paneth cell marker, from the epididymis",
abstract = "Paneth cell-like metaplasia has been reported in the epithelium of the epididymis and prostatic adenocarcinomas. We studied the expression of group II phospholipase A2 (PLA2), a marker of Paneth cell differentiation, in six orchiectomy specimens with Paneth cell-like metaplasia. Both immunohistochemistry for group II PLA2 protein and in situ hybridization for the mRNA of group II PLA2 gave negative results in all six cases but positive reaction for lysozyme. The results show that the cells of the Paneth cell-like metaplasia are not true Paneth cells.",
author = "Nevalainen, {Timo J.} and Shah, {Varsha I.} and {De PeraltaVenturina}, Mariza and Mahul Amin",
year = "2001",
month = "1",
day = "1",
doi = "10.1034/j.1600-0463.2001.d01-123.x",
language = "English (US)",
volume = "109",
pages = "295--298",
journal = "Acta pathologica et microbiologica Scandinavica",
issn = "0365-5555",
publisher = "Blackwell Munksgaard",
number = "4",

}

TY - JOUR

T1 - Absence of group II phospholipase A2, a Paneth cell marker, from the epididymis

AU - Nevalainen, Timo J.

AU - Shah, Varsha I.

AU - De PeraltaVenturina, Mariza

AU - Amin, Mahul

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Paneth cell-like metaplasia has been reported in the epithelium of the epididymis and prostatic adenocarcinomas. We studied the expression of group II phospholipase A2 (PLA2), a marker of Paneth cell differentiation, in six orchiectomy specimens with Paneth cell-like metaplasia. Both immunohistochemistry for group II PLA2 protein and in situ hybridization for the mRNA of group II PLA2 gave negative results in all six cases but positive reaction for lysozyme. The results show that the cells of the Paneth cell-like metaplasia are not true Paneth cells.

AB - Paneth cell-like metaplasia has been reported in the epithelium of the epididymis and prostatic adenocarcinomas. We studied the expression of group II phospholipase A2 (PLA2), a marker of Paneth cell differentiation, in six orchiectomy specimens with Paneth cell-like metaplasia. Both immunohistochemistry for group II PLA2 protein and in situ hybridization for the mRNA of group II PLA2 gave negative results in all six cases but positive reaction for lysozyme. The results show that the cells of the Paneth cell-like metaplasia are not true Paneth cells.

UR - http://www.scopus.com/inward/record.url?scp=0034961257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034961257&partnerID=8YFLogxK

U2 - 10.1034/j.1600-0463.2001.d01-123.x

DO - 10.1034/j.1600-0463.2001.d01-123.x

M3 - Article

VL - 109

SP - 295

EP - 298

JO - Acta pathologica et microbiologica Scandinavica

JF - Acta pathologica et microbiologica Scandinavica

SN - 0365-5555

IS - 4

ER -