Acanthamoeba infection in a patient with chronic graft-versus-host disease occurring during treatment with voriconazole

D. R. Kaul, L. Lowe, G. S. Visvesvara, S. Farmen, Yasser Khaled, G. A. Yanik

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We report a case of disseminated infection with Acanthamoeba in a patient with graft-versus-host disease after hematopoietic stem cell transplant (HSCT) for acute lymphocytic leukemia. The infection involved the brain, skin, and lungs and occurred despite treatment with voriconazole for mold prophylaxis, and did not respond to treatment with multiple other agents reported to have activity against Acanthamoeba. To our knowledge, infection with Acanthamoeba has been reported in 4 other patients after HSCT or bone marrow transplant, and our case is the first to be diagnosed ante-mortem.

Original languageEnglish (US)
Pages (from-to)437-441
Number of pages5
JournalTransplant Infectious Disease
Volume10
Issue number6
DOIs
StatePublished - Dec 1 2008

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Acanthamoeba
Graft vs Host Disease
Hematopoietic Stem Cells
Transplants
Infection
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Fungi
Therapeutics
Bone Marrow
Lung
Skin
Brain
Voriconazole

All Science Journal Classification (ASJC) codes

  • Transplantation
  • Infectious Diseases

Cite this

Acanthamoeba infection in a patient with chronic graft-versus-host disease occurring during treatment with voriconazole. / Kaul, D. R.; Lowe, L.; Visvesvara, G. S.; Farmen, S.; Khaled, Yasser; Yanik, G. A.

In: Transplant Infectious Disease, Vol. 10, No. 6, 01.12.2008, p. 437-441.

Research output: Contribution to journalArticle

Kaul, D. R. ; Lowe, L. ; Visvesvara, G. S. ; Farmen, S. ; Khaled, Yasser ; Yanik, G. A. / Acanthamoeba infection in a patient with chronic graft-versus-host disease occurring during treatment with voriconazole. In: Transplant Infectious Disease. 2008 ; Vol. 10, No. 6. pp. 437-441.
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