Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes

The health, aging, and body composition study

Won Park Seok, Bret H. Goodpaster, Elsa S. Strotmeyer, Lewis H. Kuller, Robert Broudeau, Candace Kammerer, Nathalie De Rekeneire, Tamara B. Harris, Ann V. Schwartz, Frances Tylavsky, Cho Yong-Wook, Anne B. Newman

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE - It has been shown that adults with either long-standing type 1 or type 2 diabetes had lower skeletal muscle strength than nondiabetic adults in cross-sectional studies. The aim of the study was to investigate longitudinal changes of muscle mass and strength in community-dwelling older adults with and without type 2 diabetes. RESEARCH DESIGN AND METHODS - We examined leg and arm muscle mass and strength at baseline and 3 years later in 1,840 older adults aged 70-79 years in the Health, Aging, and Body Composition Study. Regional muscle mass was measured by dual energy X-ray absorptiometry, and muscle strength was measured using isokinetic and isometric dynamometers. RESULTS - Older adults with type 2 diabetes (n = 305) showed greater declines in the leg muscle mass (-0.29 ± 0.03 vs. -0.23 ± 0.01 kg, P < 0.05) and strength (-16.5 ± 1.2 vs. -12.4 ± 0.5 Nm, P = 0.001) compared with older adults without diabetes. Leg muscle quality, expressed as maximal strength per unit of muscle mass (Newton meters per kilogram), also declined more rapidly in older adults with diabetes (-1.6 ± 0.2 vs. -1.2 ± 0.1 Nm/kg, P < 0.05). Changes in arm muscle strength and quality were not different between those with and without diabetes. Rapid declines in leg muscle strength and quality were attenuated but remained significant after controlling for demographics, body composition, physical activity, combined chronic diseases, interleukin-6, and tumor necrosis factor-α. CONCLUSIONS - In older adults, type 2 diabetes is associated with accelerated loss of leg muscle strength and quality.

Original languageEnglish (US)
Pages (from-to)1507-1512
Number of pages6
JournalDiabetes Care
Volume30
Issue number6
DOIs
StatePublished - May 1 2007

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Muscle Strength
Body Composition
Type 2 Diabetes Mellitus
Skeletal Muscle
Leg
Health
Muscles
Arm
Independent Living
Photon Absorptiometry
Interleukin-6
Chronic Disease
Research Design
Tumor Necrosis Factor-alpha
Cross-Sectional Studies
Demography

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Seok, W. P., Goodpaster, B. H., Strotmeyer, E. S., Kuller, L. H., Broudeau, R., Kammerer, C., ... Newman, A. B. (2007). Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: The health, aging, and body composition study. Diabetes Care, 30(6), 1507-1512. https://doi.org/10.2337/dc06-2537

Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes : The health, aging, and body composition study. / Seok, Won Park; Goodpaster, Bret H.; Strotmeyer, Elsa S.; Kuller, Lewis H.; Broudeau, Robert; Kammerer, Candace; De Rekeneire, Nathalie; Harris, Tamara B.; Schwartz, Ann V.; Tylavsky, Frances; Yong-Wook, Cho; Newman, Anne B.

In: Diabetes Care, Vol. 30, No. 6, 01.05.2007, p. 1507-1512.

Research output: Contribution to journalArticle

Seok, WP, Goodpaster, BH, Strotmeyer, ES, Kuller, LH, Broudeau, R, Kammerer, C, De Rekeneire, N, Harris, TB, Schwartz, AV, Tylavsky, F, Yong-Wook, C & Newman, AB 2007, 'Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: The health, aging, and body composition study', Diabetes Care, vol. 30, no. 6, pp. 1507-1512. https://doi.org/10.2337/dc06-2537
Seok, Won Park ; Goodpaster, Bret H. ; Strotmeyer, Elsa S. ; Kuller, Lewis H. ; Broudeau, Robert ; Kammerer, Candace ; De Rekeneire, Nathalie ; Harris, Tamara B. ; Schwartz, Ann V. ; Tylavsky, Frances ; Yong-Wook, Cho ; Newman, Anne B. / Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes : The health, aging, and body composition study. In: Diabetes Care. 2007 ; Vol. 30, No. 6. pp. 1507-1512.
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abstract = "OBJECTIVE - It has been shown that adults with either long-standing type 1 or type 2 diabetes had lower skeletal muscle strength than nondiabetic adults in cross-sectional studies. The aim of the study was to investigate longitudinal changes of muscle mass and strength in community-dwelling older adults with and without type 2 diabetes. RESEARCH DESIGN AND METHODS - We examined leg and arm muscle mass and strength at baseline and 3 years later in 1,840 older adults aged 70-79 years in the Health, Aging, and Body Composition Study. Regional muscle mass was measured by dual energy X-ray absorptiometry, and muscle strength was measured using isokinetic and isometric dynamometers. RESULTS - Older adults with type 2 diabetes (n = 305) showed greater declines in the leg muscle mass (-0.29 ± 0.03 vs. -0.23 ± 0.01 kg, P < 0.05) and strength (-16.5 ± 1.2 vs. -12.4 ± 0.5 Nm, P = 0.001) compared with older adults without diabetes. Leg muscle quality, expressed as maximal strength per unit of muscle mass (Newton meters per kilogram), also declined more rapidly in older adults with diabetes (-1.6 ± 0.2 vs. -1.2 ± 0.1 Nm/kg, P < 0.05). Changes in arm muscle strength and quality were not different between those with and without diabetes. Rapid declines in leg muscle strength and quality were attenuated but remained significant after controlling for demographics, body composition, physical activity, combined chronic diseases, interleukin-6, and tumor necrosis factor-α. CONCLUSIONS - In older adults, type 2 diabetes is associated with accelerated loss of leg muscle strength and quality.",
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AU - Kuller, Lewis H.

AU - Broudeau, Robert

AU - Kammerer, Candace

AU - De Rekeneire, Nathalie

AU - Harris, Tamara B.

AU - Schwartz, Ann V.

AU - Tylavsky, Frances

AU - Yong-Wook, Cho

AU - Newman, Anne B.

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N2 - OBJECTIVE - It has been shown that adults with either long-standing type 1 or type 2 diabetes had lower skeletal muscle strength than nondiabetic adults in cross-sectional studies. The aim of the study was to investigate longitudinal changes of muscle mass and strength in community-dwelling older adults with and without type 2 diabetes. RESEARCH DESIGN AND METHODS - We examined leg and arm muscle mass and strength at baseline and 3 years later in 1,840 older adults aged 70-79 years in the Health, Aging, and Body Composition Study. Regional muscle mass was measured by dual energy X-ray absorptiometry, and muscle strength was measured using isokinetic and isometric dynamometers. RESULTS - Older adults with type 2 diabetes (n = 305) showed greater declines in the leg muscle mass (-0.29 ± 0.03 vs. -0.23 ± 0.01 kg, P < 0.05) and strength (-16.5 ± 1.2 vs. -12.4 ± 0.5 Nm, P = 0.001) compared with older adults without diabetes. Leg muscle quality, expressed as maximal strength per unit of muscle mass (Newton meters per kilogram), also declined more rapidly in older adults with diabetes (-1.6 ± 0.2 vs. -1.2 ± 0.1 Nm/kg, P < 0.05). Changes in arm muscle strength and quality were not different between those with and without diabetes. Rapid declines in leg muscle strength and quality were attenuated but remained significant after controlling for demographics, body composition, physical activity, combined chronic diseases, interleukin-6, and tumor necrosis factor-α. CONCLUSIONS - In older adults, type 2 diabetes is associated with accelerated loss of leg muscle strength and quality.

AB - OBJECTIVE - It has been shown that adults with either long-standing type 1 or type 2 diabetes had lower skeletal muscle strength than nondiabetic adults in cross-sectional studies. The aim of the study was to investigate longitudinal changes of muscle mass and strength in community-dwelling older adults with and without type 2 diabetes. RESEARCH DESIGN AND METHODS - We examined leg and arm muscle mass and strength at baseline and 3 years later in 1,840 older adults aged 70-79 years in the Health, Aging, and Body Composition Study. Regional muscle mass was measured by dual energy X-ray absorptiometry, and muscle strength was measured using isokinetic and isometric dynamometers. RESULTS - Older adults with type 2 diabetes (n = 305) showed greater declines in the leg muscle mass (-0.29 ± 0.03 vs. -0.23 ± 0.01 kg, P < 0.05) and strength (-16.5 ± 1.2 vs. -12.4 ± 0.5 Nm, P = 0.001) compared with older adults without diabetes. Leg muscle quality, expressed as maximal strength per unit of muscle mass (Newton meters per kilogram), also declined more rapidly in older adults with diabetes (-1.6 ± 0.2 vs. -1.2 ± 0.1 Nm/kg, P < 0.05). Changes in arm muscle strength and quality were not different between those with and without diabetes. Rapid declines in leg muscle strength and quality were attenuated but remained significant after controlling for demographics, body composition, physical activity, combined chronic diseases, interleukin-6, and tumor necrosis factor-α. CONCLUSIONS - In older adults, type 2 diabetes is associated with accelerated loss of leg muscle strength and quality.

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