Accessory proteins for heterotrimeric g-proteins in the kidney

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Heterotrimeric G-proteins play a fundamentally important role in regulating signal transduction pathways in the kidney. Accessory proteins are being identified as direct binding partners for heterotrimeric G-protein α or βγ subunits to promote more diverse mechanisms by which G-protein signaling is controlled. In some instances, accessory proteins can modulate the signaling magnitude, localization, and duration following the activation of cell membrane-associated receptors. Alternatively, accessory proteins complexed with their G-protein α or βγ subunits can promote non-canonical models of signaling activity within the cell. In this review, we will highlight the expression profile, localization and functional importance of these newly identified accessory proteins to control the function of select G-protein subunits under normal and various disease conditions observed in the kidney.

Original languageEnglish (US)
Article number219
JournalFrontiers in Physiology
Volume6
Issue numberAug
DOIs
StatePublished - Jan 1 2015

Fingerprint

Protein Subunits
GTP-Binding Proteins
Kidney
Heterotrimeric GTP-Binding Proteins
Proteins
Signal Transduction
Cell Membrane

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Accessory proteins for heterotrimeric g-proteins in the kidney. / Park, Frank.

In: Frontiers in Physiology, Vol. 6, No. Aug, 219, 01.01.2015.

Research output: Contribution to journalReview article

@article{d8789b3f634b45e09ef209e0efd9587f,
title = "Accessory proteins for heterotrimeric g-proteins in the kidney",
abstract = "Heterotrimeric G-proteins play a fundamentally important role in regulating signal transduction pathways in the kidney. Accessory proteins are being identified as direct binding partners for heterotrimeric G-protein α or βγ subunits to promote more diverse mechanisms by which G-protein signaling is controlled. In some instances, accessory proteins can modulate the signaling magnitude, localization, and duration following the activation of cell membrane-associated receptors. Alternatively, accessory proteins complexed with their G-protein α or βγ subunits can promote non-canonical models of signaling activity within the cell. In this review, we will highlight the expression profile, localization and functional importance of these newly identified accessory proteins to control the function of select G-protein subunits under normal and various disease conditions observed in the kidney.",
author = "Frank Park",
year = "2015",
month = "1",
day = "1",
doi = "10.3389/fphys.2015.00219",
language = "English (US)",
volume = "6",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Research Foundation",
number = "Aug",

}

TY - JOUR

T1 - Accessory proteins for heterotrimeric g-proteins in the kidney

AU - Park, Frank

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Heterotrimeric G-proteins play a fundamentally important role in regulating signal transduction pathways in the kidney. Accessory proteins are being identified as direct binding partners for heterotrimeric G-protein α or βγ subunits to promote more diverse mechanisms by which G-protein signaling is controlled. In some instances, accessory proteins can modulate the signaling magnitude, localization, and duration following the activation of cell membrane-associated receptors. Alternatively, accessory proteins complexed with their G-protein α or βγ subunits can promote non-canonical models of signaling activity within the cell. In this review, we will highlight the expression profile, localization and functional importance of these newly identified accessory proteins to control the function of select G-protein subunits under normal and various disease conditions observed in the kidney.

AB - Heterotrimeric G-proteins play a fundamentally important role in regulating signal transduction pathways in the kidney. Accessory proteins are being identified as direct binding partners for heterotrimeric G-protein α or βγ subunits to promote more diverse mechanisms by which G-protein signaling is controlled. In some instances, accessory proteins can modulate the signaling magnitude, localization, and duration following the activation of cell membrane-associated receptors. Alternatively, accessory proteins complexed with their G-protein α or βγ subunits can promote non-canonical models of signaling activity within the cell. In this review, we will highlight the expression profile, localization and functional importance of these newly identified accessory proteins to control the function of select G-protein subunits under normal and various disease conditions observed in the kidney.

UR - http://www.scopus.com/inward/record.url?scp=84940929506&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940929506&partnerID=8YFLogxK

U2 - 10.3389/fphys.2015.00219

DO - 10.3389/fphys.2015.00219

M3 - Review article

VL - 6

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

IS - Aug

M1 - 219

ER -