Acetylcholine and Olfactory Perceptual Learning

Donald A. Wilson, Max Fletcher, Regina M. Sullivan

Research output: Contribution to journalReview article

87 Citations (Scopus)

Abstract

Olfactory perceptual learning is a relatively long-term, learned increase in perceptual acuity, and has been described in both humans and animals. Data from recent electrophysiological studies have indicated that olfactory perceptual learning may be correlated with changes in odorant receptive fields of neurons in the olfactory bulb and piriform cortex. These changes include enhanced representation of the molecular features of familiar odors by mitral cells in the olfactory bulb, and synthetic coding of multiple coincident odorant features into odor objects by cortical neurons. In this paper, data are reviewed that show the critical role of acetylcholine (Ach) in olfactory system function and plasticity, and cholinergic modulation of olfactory perceptual learning at both the behavioral and cortical level.

Original languageEnglish (US)
Pages (from-to)28-34
Number of pages7
JournalLearning and Memory
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2004

Fingerprint

Acetylcholine
Learning
Olfactory Bulb
Neurons
Cholinergic Agents
Odorants

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Acetylcholine and Olfactory Perceptual Learning. / Wilson, Donald A.; Fletcher, Max; Sullivan, Regina M.

In: Learning and Memory, Vol. 11, No. 1, 01.01.2004, p. 28-34.

Research output: Contribution to journalReview article

Wilson, Donald A. ; Fletcher, Max ; Sullivan, Regina M. / Acetylcholine and Olfactory Perceptual Learning. In: Learning and Memory. 2004 ; Vol. 11, No. 1. pp. 28-34.
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