Activated factor IX complex in treatment of surgical cases of hemophilia A with inhibitors

Wahid Hanna, R. R. Madigan, M. A. Miles, R. D. Lange

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Three patients with severe hemophilia A with inhibitors to factor VIII were treated with activated factor IX complex. Bleeding was controlled adequately during surgical procedures involving each of the three. Partial thromboplastin times showed a variable shortening and prothrombin times were significantly shortened to values less than normal. Hemostasis was substantiated by the use of epsilon aminocaproic acid. Neither anamnestic responses nor thrombotic complications were observed. A transient hypertension developed in two patients shortly after infusion with the activated factor IX complex.

Original languageEnglish (US)
Pages (from-to)638-641
Number of pages4
JournalThrombosis and Haemostasis
Volume46
Issue number3
StatePublished - Jan 1 1981

Fingerprint

Factor IXa
Factor IX
Hemophilia A
Aminocaproic Acid
Partial Thromboplastin Time
Prothrombin Time
Factor VIII
Hemostasis
Reference Values
Hemorrhage
Hypertension
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Activated factor IX complex in treatment of surgical cases of hemophilia A with inhibitors. / Hanna, Wahid; Madigan, R. R.; Miles, M. A.; Lange, R. D.

In: Thrombosis and Haemostasis, Vol. 46, No. 3, 01.01.1981, p. 638-641.

Research output: Contribution to journalArticle

Hanna, Wahid ; Madigan, R. R. ; Miles, M. A. ; Lange, R. D. / Activated factor IX complex in treatment of surgical cases of hemophilia A with inhibitors. In: Thrombosis and Haemostasis. 1981 ; Vol. 46, No. 3. pp. 638-641.
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