Activation of β-noradrenergic receptors enhances rhythmic bursting in mouse olfactory bulb external tufted cells

Fuwen Zhou, Hongwei Dong, Matthew Ennis

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The main olfactory bulb (MOB) receives a rich noradrenergic innervation from the nucleus locus coeruleus. Despite the well-documented role of norepinephrine and β-adrenergic receptors in neonatal odor preference learning, identified cellular physiological actions of β-receptors in the MOB have remained elusive. β-Receptors are expressed at relatively high levels in the MOB glomeruli, the location of external tufted (ET) cells that exert an excitatory drive on mitral and other cell types. The present study investigated the effects of β-receptor activation on the excitability of ET cells with patchclamp electrophysiology in mature mouse MOB slices. Isoproterenol and selective β2-, but not β1-, receptor agonists were found to enhance two key intrinsic currents involved in ET burst initiation: persistent sodium (INaP) and hyperpolarization-activated inward (Ih) currents. Together, the positive modulation of these currents increased the frequency and strength of ET cell rhythmic bursting. Rodent sniff frequency and locus coeruleus neuronal firing increase in response to novel stimuli or environments. The increase in ET excitability by β-receptor activation may better enable ET cell rhythmic bursting, and hence glomerular network activity, to pace faster sniff rates during heightened norepinephrine release associated with arousal.

Original languageEnglish (US)
Pages (from-to)2604-2614
Number of pages11
JournalJournal of neurophysiology
Volume116
Issue number6
DOIs
StatePublished - Dec 1 2016

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Olfactory Bulb
Locus Coeruleus
Adrenergic Receptors
Electrophysiology
Arousal
Isoproterenol
Rodentia
Norepinephrine
Sodium
Learning

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology

Cite this

Activation of β-noradrenergic receptors enhances rhythmic bursting in mouse olfactory bulb external tufted cells. / Zhou, Fuwen; Dong, Hongwei; Ennis, Matthew.

In: Journal of neurophysiology, Vol. 116, No. 6, 01.12.2016, p. 2604-2614.

Research output: Contribution to journalArticle

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