Activation of complement in human serum by some synthetic polymers used for intraocular lenses

R. Joseph Gobel, Jarmila Janatova, Joseph Googe, David J. Apple

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Determination of the potential to activate complement can be used as one criterion in testing the biocompatibility of various synthetic polymers that are utilized in the medical field. Intraocular lenSE5 (lOLs) made of poly(methyl methacrylate) (PMMA) with PMMA loops, poly(hydroxyethyl methacrylate) (PHEMA) lenses, silicone lenSE5 and PMMA lenSE5 with polypropylene loops were examined in this study. The concentrations of the activation peptides C3a, C4a and C5a were measured by radioimmunoassay (r.i.a.) in human serum after incubation with and without lOLs for up to 12 h. The presence of silicone lenSE5 caused an increase in C3a levels. In the presence of polypropylene loops, the concentrations of both C3a and C5a were significantly higher than in serum incubated alone. There was no statistically significant increase in the concentration of C4a caused by any of the materials tested. The results suggest that lOLs made from silicone or lenSE5 with polypropylene loops activate the complement system via the alternative pathway.

Original languageEnglish (US)
Pages (from-to)285-288
Number of pages4
JournalBiomaterials
Volume8
Issue number4
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

Fingerprint

Intraocular lenses
Polypropylenes
Complement Activation
Intraocular Lenses
Polymethyl Methacrylate
Silicones
Polymethyl methacrylates
Polymers
Chemical activation
Serum
Materials Testing
Biocompatibility
Peptides
Lenses
Radioimmunoassay
Testing

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Activation of complement in human serum by some synthetic polymers used for intraocular lenses. / Gobel, R. Joseph; Janatova, Jarmila; Googe, Joseph; Apple, David J.

In: Biomaterials, Vol. 8, No. 4, 01.01.1987, p. 285-288.

Research output: Contribution to journalArticle

Gobel, R. Joseph ; Janatova, Jarmila ; Googe, Joseph ; Apple, David J. / Activation of complement in human serum by some synthetic polymers used for intraocular lenses. In: Biomaterials. 1987 ; Vol. 8, No. 4. pp. 285-288.
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