Activation of serotonin receptors modulates synaptic transmission in rat cerebral cortex

Fuming Zhou, John J. Hablitz

Research output: Contribution to journalArticle

179 Citations (Scopus)

Abstract

The cerebral cortex receives an extensive serotonergic (5- hydroxytryptamine, 5-HT) input. Immunohistochemical studies suggest that inhibitory neurons are the main target of 5-HT innervation. In vivo extracellular recordings have shown that 5-HT generally inhibited cortical pyramidal neurons, whereas in vitro studies have shown an excitatory action. To determine the cellular mechanisms underlying the diverse actions of 5-HT in the cortex, we examined its effects on cortical inhibitory interneurons and pyramidal neurons. We found that 5-HT, through activation of 5-HT(2A) receptors, induced a massive enhancement of spontaneous inhibitory postsynaptic currents (sIPSCs) in pyramidal neurons, lasting for ~6 min. In interneurons, this 5-HT-induced enhancement of sIPSCs was much weaker. Activation of 5-HT(2A) receptors also increased spontaneous excitatory postsynaptic currents (sEPSCs) in pyramidal neurons. This response desensitized less and at a slower rate. In contrast, 5-HT slightly decreased evoked IPSCs (eIPSCs) and eEPSCs. In addition, 5-HT via 5-HT3 receptors evoked a large and rapidly desensitizing inward current in a subset of interneurons and induced a transient enhancement of sIPSCs. Our results suggest that 5-HT has widespread effects on both interneurons and pyramidal neurons and that a short pulse of 5-HT is likely to induce inhibition whereas the prolonged presence of 5-HT may result in excitation.

Original languageEnglish (US)
Pages (from-to)2989-2999
Number of pages11
JournalJournal of neurophysiology
Volume82
Issue number6
StatePublished - Dec 1 1999

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Serotonin Receptors
Synaptic Transmission
Cerebral Cortex
Serotonin
Pyramidal Cells
Interneurons
Inhibitory Postsynaptic Potentials
Receptors, Serotonin, 5-HT3
Excitatory Postsynaptic Potentials
Neurons

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology

Cite this

Activation of serotonin receptors modulates synaptic transmission in rat cerebral cortex. / Zhou, Fuming; Hablitz, John J.

In: Journal of neurophysiology, Vol. 82, No. 6, 01.12.1999, p. 2989-2999.

Research output: Contribution to journalArticle

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