Activators of G protein signaling in the kidney

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Heterotrimeric G proteins play a crucial role in regulating signal processing to maintain normal cellular homeostasis, and subtle perturbations in its activity can potentially lead to the pathogenesis of renal disorders or diseases. Cell-surface receptors and accessory proteins, which normally modify and organize the coupling of individual G protein subunits, contribute to the regulation of heterotrimeric G protein activity and their convergence and/or divergence of downstream signaling initiated by effector systems. Activators of G protein signaling (AGS) are a family of accessory proteins that intervene at multiple distinct points during the activation-inactivation cycle of G proteins, even in the absence of receptor stimulation. Perturbations in the expression of individual AGS proteins have been reported tomodulate signal transduction pathways in a wide array of diseases and disorders within the brain, heart, immune system, and more recently, the kidney. This review will provide an overview of the expression profile, localization, and putative biologic role of the AGS family in the context of normal and diseased states of the kidney.

Original languageEnglish (US)
Pages (from-to)235-245
Number of pages11
JournalJournal of Pharmacology and Experimental Therapeutics
Volume353
Issue number2
DOIs
StatePublished - May 1 2015

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GTP-Binding Proteins
Kidney
Heterotrimeric GTP-Binding Proteins
Proteins
Protein Subunits
Kidney Diseases
Cell Surface Receptors
Brain Diseases
Immune System
Signal Transduction
Homeostasis

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Activators of G protein signaling in the kidney. / Park, Frank.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 353, No. 2, 01.05.2015, p. 235-245.

Research output: Contribution to journalReview article

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