Activity energy expenditure and incident cognitive impairment in older adults

Laura E. Middleton, Todd M. Manini, Eleanor M. Simonsick, Tamara B. Harris, Deborah E. Barnes, Frances Tylavsky, Jennifer S. Brach, James E. Everhart, Kristine Yaffe

Research output: Contribution to journalArticle

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Abstract

Background: Studies suggest that physically active people have reduced risk of incident cognitive impairment in late life. However, these studies are limited by reliance on self-reports of physical activity, which only moderately correlate with objective measures and often exclude activity not readily quantifiable by frequency and duration. The objective of this study was to investigate the relationship between activity energy expenditure (AEE), an objective measure of total activity, and incidence of cognitive impairment. Methods: We calculated AEE as 90% of total energy expenditure (assessed during 2 weeks using doubly labeled water) minus resting metabolic rate (measured using indirect calorimetry) in 197 men and women (mean age, 74.8 years) who were free of mobility and cognitive impairments at study baseline (1998-1999). Cognitive function was assessed at baseline and 2 or 5 years later using the Modified Mini-Mental State Examination. Cognitive impairment was defined as a decline of at least 1.0 SD (9 points) between baseline and follow-up evaluations. Results: After adjustment for baseline Modified Mini- Mental State Examination scores, demographics, fatfree mass, sleep duration, self-reported health, and diabetes mellitus, older adults in the highest sex-specific tertile of AEE had lower odds of incident cognitive impairment than those in the lowest tertile (odds ratio, 0.09; 95% confidence interval, 0.01-0.79). There was also a significant dose response between AEE and incidence of cognitive impairment (P=.05 for trend over tertiles). Conclusions: These findings indicate that greater AEE may be protective against cognitive impairment in a dose-response manner. The significance of overall activity in contrast to vigorous or light activity should be determined.

Original languageEnglish (US)
Pages (from-to)1251-1257
Number of pages7
JournalArchives of Internal Medicine
Volume171
Issue number14
DOIs
StatePublished - Jul 25 2011

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Energy Metabolism
Basal Metabolism
Indirect Calorimetry
Incidence
Cognitive Dysfunction
Self Report
Cognition
Diabetes Mellitus
Sleep
Odds Ratio
Demography
Confidence Intervals
Exercise
Light
Water
Health

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Middleton, L. E., Manini, T. M., Simonsick, E. M., Harris, T. B., Barnes, D. E., Tylavsky, F., ... Yaffe, K. (2011). Activity energy expenditure and incident cognitive impairment in older adults. Archives of Internal Medicine, 171(14), 1251-1257. https://doi.org/10.1001/archinternmed.2011.277

Activity energy expenditure and incident cognitive impairment in older adults. / Middleton, Laura E.; Manini, Todd M.; Simonsick, Eleanor M.; Harris, Tamara B.; Barnes, Deborah E.; Tylavsky, Frances; Brach, Jennifer S.; Everhart, James E.; Yaffe, Kristine.

In: Archives of Internal Medicine, Vol. 171, No. 14, 25.07.2011, p. 1251-1257.

Research output: Contribution to journalArticle

Middleton, LE, Manini, TM, Simonsick, EM, Harris, TB, Barnes, DE, Tylavsky, F, Brach, JS, Everhart, JE & Yaffe, K 2011, 'Activity energy expenditure and incident cognitive impairment in older adults', Archives of Internal Medicine, vol. 171, no. 14, pp. 1251-1257. https://doi.org/10.1001/archinternmed.2011.277
Middleton, Laura E. ; Manini, Todd M. ; Simonsick, Eleanor M. ; Harris, Tamara B. ; Barnes, Deborah E. ; Tylavsky, Frances ; Brach, Jennifer S. ; Everhart, James E. ; Yaffe, Kristine. / Activity energy expenditure and incident cognitive impairment in older adults. In: Archives of Internal Medicine. 2011 ; Vol. 171, No. 14. pp. 1251-1257.
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