Activity influences on soleus muscle myosin during rodent hindlimb suspension

Donald Thomason, R. E. Herrick, K. M. Baldwin

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

This study examined the effect of stationary ground support (2 and 4 h/day) and uphill running (1.5 h/day, 20 m/min, 30% grade) activity patterns on soleus muscle atrophy and slow myosin loss during 4 wk of rodent hindlimb unweighting by tail suspension. We also examined the effect of uphill running during the last 4 wk of an 8-wk hindlimb unweighting program and during 4 wk of cage recovery after 4 wk of hindlimb unweighting. All forms of activity partially spared soleus muscle weight (mg), myofibril protein (mg/muscle pair and μg/mg muscle), and relative and absolute slwo myosin (SM) isoform content (% of total and mg/muscle pair, P < 0.05). Relative to the normal control soleus muscle, the uphill running regimens resulted in 1) increased fast myosin isoform content and 2) diminished recovery of SM isoform content when coupled with cage activity recovery. Four weeks of cage recovery after 4 wk of hindlimb unweighting resulted in recovery of the relative SM isoform content to proportions exceeding normal control values, suggesting an apparent degradation of any normally existing fast myosin. These results indicate that, in the context of the hindlimb unweighting model, the mechanisms controlling the expression of soleus muscle SM and fast myosin genes can be affected differently by the diverse activities of stationary ground support, unrestricted cage activity, and programmed uphill running.

Original languageEnglish (US)
Pages (from-to)138-144
Number of pages7
JournalJournal of Applied Physiology
Volume63
Issue number1
StatePublished - 1987
Externally publishedYes

Fingerprint

Hindlimb Suspension
Myosins
Rodentia
Skeletal Muscle
Hindlimb
Running
Protein Isoforms
Muscles
Muscular Atrophy
Muscle Proteins
Myofibrils
Reference Values
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Activity influences on soleus muscle myosin during rodent hindlimb suspension. / Thomason, Donald; Herrick, R. E.; Baldwin, K. M.

In: Journal of Applied Physiology, Vol. 63, No. 1, 1987, p. 138-144.

Research output: Contribution to journalArticle

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