Acute effect of nicotine on non-smokers

II. MLRs and 40-Hz responses

Ashley Harkrider, Craig A. Champlin

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This paper is the second in a series of three investigating the role of cholinergic mechanisms in the auditory system by assessing the acute effects of nicotine, an acetylcholinomimetic drug, on aggregate responses within the auditory pathway. In a single-blind procedure, auditory responses were obtained from 20 normal-hearing, non-smokers (10 male) under two conditions (nicotine, placebo). The effects of nicotine on central, mesogenous responses of the auditory system (middle latency and 40-Hz responses) are described in this second paper. Results indicated that transdermal administration of nicotine to non-smokers does significantly affect the central, neural transmission of acoustic information. Na-Pa amplitude and Nb latency of the middle latency response and latency measures of the 40-Hz response were acutely altered by the presence of nicotine.

Original languageEnglish (US)
Pages (from-to)89-98
Number of pages10
JournalHearing Research
Volume160
Issue number1-2
DOIs
StatePublished - Oct 16 2001

Fingerprint

Nicotine
Cutaneous Administration
Auditory Pathways
Acoustics
Synaptic Transmission
Cholinergic Agents
Hearing
Reaction Time
Placebos
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Sensory Systems

Cite this

Acute effect of nicotine on non-smokers : II. MLRs and 40-Hz responses. / Harkrider, Ashley; Champlin, Craig A.

In: Hearing Research, Vol. 160, No. 1-2, 16.10.2001, p. 89-98.

Research output: Contribution to journalArticle

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