Acute effect of nicotine on non-smokers: III. LLRs and EEGs

Ashley Harkrider, Craig A. Champlin

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This paper is the last in a series of three investigating the role of cholinergic mechanisms in the auditory system by assessing the acute effects of nicotine, an acetylcholinomimetic drug, on aggregate responses within the auditory pathway. In a single-blind procedure, auditory responses were obtained from 20 normal-hearing, non-smokers (10 male) under two conditions (nicotine, placebo). The effects of nicotine on long-latency responses of the auditory system and on electroencephalograms are described in this paper. Results indicated that transdermal administration of nicotine to non-smokers significantly affects the afferent and efferent transmission of acoustic information, as well as enhancing cortical activation. Long-latency response amplitudes and electroencephalogram activity (dominant power and frequencies) were altered by acute doses of transdermal nicotine.

Original languageEnglish (US)
Pages (from-to)99-110
Number of pages12
JournalHearing Research
Volume160
Issue number1-2
DOIs
StatePublished - Oct 16 2001
Externally publishedYes

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Nicotine
Electroencephalography
Reaction Time
Cutaneous Administration
Auditory Pathways
Acoustics
Cholinergic Agents
Hearing
Placebos
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Sensory Systems

Cite this

Acute effect of nicotine on non-smokers : III. LLRs and EEGs. / Harkrider, Ashley; Champlin, Craig A.

In: Hearing Research, Vol. 160, No. 1-2, 16.10.2001, p. 99-110.

Research output: Contribution to journalArticle

Harkrider, Ashley ; Champlin, Craig A. / Acute effect of nicotine on non-smokers : III. LLRs and EEGs. In: Hearing Research. 2001 ; Vol. 160, No. 1-2. pp. 99-110.
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