Acute fulminant lactic acidosis complicating metastatic cholangiocarcinoma

Barry Wall, Nawar Mansour, C. Robert Cooke

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A patient with cholangiocarcinoma, metastatic to the liver and lungs, developed acute fulminant lactic acidosis in the absence of overt hepatic failure, sepsis, hypoxia, or circulatory failure. Despite extensive tumor replacement of hepatic parenchyma, no acid-base disorder was present during initial evaluation. The onset of acute lactic acidosis was temporally associated with the development of otherwise asymptomatic episodes of intermittent atrial arrhythmias. Once established, lactic acidosis was inexorably progressive, despite resolution of arrhythmias. Extensive areas of acute necrosis within the large hepatic metastases were demonstrated on postmortem examination, suggesting that local tissue ischemia, precipitated by cardiac arrhythmias, lead to excessive lactic acid production.

Original languageEnglish (US)
Pages (from-to)126-129
Number of pages4
JournalAmerican Journal of the Medical Sciences
Volume319
Issue number2
DOIs
StatePublished - Jan 1 2000

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Lactic Acidosis
Cholangiocarcinoma
Cardiac Arrhythmias
Liver
Liver Failure
Autopsy
Shock
Lactic Acid
Sepsis
Necrosis
Ischemia
Neoplasm Metastasis
Lung
Acids
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Acute fulminant lactic acidosis complicating metastatic cholangiocarcinoma. / Wall, Barry; Mansour, Nawar; Cooke, C. Robert.

In: American Journal of the Medical Sciences, Vol. 319, No. 2, 01.01.2000, p. 126-129.

Research output: Contribution to journalArticle

Wall, Barry ; Mansour, Nawar ; Cooke, C. Robert. / Acute fulminant lactic acidosis complicating metastatic cholangiocarcinoma. In: American Journal of the Medical Sciences. 2000 ; Vol. 319, No. 2. pp. 126-129.
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