Acute kidney dysfunction in patients with chronic hepatitis C virus infection

Analysis of viral and non-viral factors

Sanjaya Satapathy, Chandra S. Lingisetty, Susan E. Williams

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Multiple studies have shown a relationship between chronic hepatitis C infection and chronic kidney disease. The prevalence, severity, underlying etiologies and predictors of acute kidney dysfunction (AKD) events in patients with hepatitis C has not been studied. Methods: We investigated viral and non-viral factors in the development renal dysfunction in 468 HCV patients retrospectively over a period of observation ranging from 3 months to 6 yrs. Results: A total of 124 AKD events occurred in 63 patients. On regression analysis; gender, race, alcohol abuse, HIV (Human immune deficiency virus) status, body mass index, baseline viral load (HCV-PCR), and genotype did not predict an event of AKD. Decompensated liver disease, history of IVDU, diabetes mellitus and baseline creatinine were independent predictors of AKD. Conclusion: Development of AKD in patient with hepatitis C virus infection is independent of the genotype and viral load at baseline and is mostly predisposed by known prevalent factors in patients with hepatitis C such as diabetes, hypertension and intravenous drug use. Decompensated liver disease is the single most viral-related factor that predisposes for AKD.

Original languageEnglish (US)
Pages (from-to)8-13
Number of pages6
JournalJournal of Clinical and Experimental Hepatology
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2014

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Chronic Hepatitis C
Virus Diseases
Hepacivirus
Kidney
Hepatitis C
Viral Load
Liver Diseases
Genotype
Chronic Renal Insufficiency
Alcoholism
Creatinine
Diabetes Mellitus
Body Mass Index
Regression Analysis
Observation
Hypertension
Viruses
Polymerase Chain Reaction
Infection
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

Acute kidney dysfunction in patients with chronic hepatitis C virus infection : Analysis of viral and non-viral factors. / Satapathy, Sanjaya; Lingisetty, Chandra S.; Williams, Susan E.

In: Journal of Clinical and Experimental Hepatology, Vol. 4, No. 1, 01.01.2014, p. 8-13.

Research output: Contribution to journalArticle

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abstract = "Background: Multiple studies have shown a relationship between chronic hepatitis C infection and chronic kidney disease. The prevalence, severity, underlying etiologies and predictors of acute kidney dysfunction (AKD) events in patients with hepatitis C has not been studied. Methods: We investigated viral and non-viral factors in the development renal dysfunction in 468 HCV patients retrospectively over a period of observation ranging from 3 months to 6 yrs. Results: A total of 124 AKD events occurred in 63 patients. On regression analysis; gender, race, alcohol abuse, HIV (Human immune deficiency virus) status, body mass index, baseline viral load (HCV-PCR), and genotype did not predict an event of AKD. Decompensated liver disease, history of IVDU, diabetes mellitus and baseline creatinine were independent predictors of AKD. Conclusion: Development of AKD in patient with hepatitis C virus infection is independent of the genotype and viral load at baseline and is mostly predisposed by known prevalent factors in patients with hepatitis C such as diabetes, hypertension and intravenous drug use. Decompensated liver disease is the single most viral-related factor that predisposes for AKD.",
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