Acute leukemia in countries with limited resources

Raul C. Ribeiro, Scott Howard, Ching Hon Pui

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Introduction Complex interactions between genetic and environmental factors underlie the etiologies of pediatric leukemias and lymphomas. Thus, it is not surprising that the incidence rates for these disorders vary widely across geographic regions (Table 24.1). In contrast to the wealth of etiologic and epidemiologic data on pediatric cancers in the United States, comparable information is not available for most countries (which lack population-based registries and adequate diagnostic methods); for that reason, only marked discrepancies in cancer incidence can be noted among regions. For example, non-Hodgkin lymphoma (NHL) of the mature B-cell immunophenotype (Burkitt lymphoma) is the most common malignancy in many African countries. Environmental factors, including infectious agents such as Epstein–Barr virus and malaria (highly prevalent in these regions), appear to contribute to the etiology of this disease. The high relative incidence of Burkitt lymphoma in these regions is even more remarkable in view of the generally lower incidence of acute lymphoblastic leukemia (ALL) in blacks compared to whites. Other examples include an increased incidence of Kaposi sarcoma in children in regions with a high rate of endemic HIV infection, of acute promyelocytic leukemia in people of Italian or Hispanic heritage, of acute myeloid leukemia (AML) presenting with chloroma in Turkey, and of T-cell ALL in children from India and Egypt. Given these empiric observations on a limited number of countries, it is not surprising that the distribution of pediatric cancers shows substantial variation across the world's regions.

Original languageEnglish (US)
Title of host publicationChildhood Leukemias, Second Edition
PublisherCambridge University Press
Pages625-638
Number of pages14
ISBN (Electronic)9780511471001
ISBN (Print)0521825199, 9780521825191
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

Fingerprint

Leukemia
Incidence
Burkitt Lymphoma
Pediatrics
Neoplasms
Myeloid Sarcoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Acute Promyelocytic Leukemia
Egypt
Kaposi's Sarcoma
Turkey
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hispanic Americans
Acute Myeloid Leukemia
Non-Hodgkin's Lymphoma
Malaria
HIV Infections
Registries
India
Lymphoma

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ribeiro, R. C., Howard, S., & Pui, C. H. (2006). Acute leukemia in countries with limited resources. In Childhood Leukemias, Second Edition (pp. 625-638). Cambridge University Press. https://doi.org/10.1017/CBO9780511471001.025

Acute leukemia in countries with limited resources. / Ribeiro, Raul C.; Howard, Scott; Pui, Ching Hon.

Childhood Leukemias, Second Edition. Cambridge University Press, 2006. p. 625-638.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ribeiro, RC, Howard, S & Pui, CH 2006, Acute leukemia in countries with limited resources. in Childhood Leukemias, Second Edition. Cambridge University Press, pp. 625-638. https://doi.org/10.1017/CBO9780511471001.025
Ribeiro RC, Howard S, Pui CH. Acute leukemia in countries with limited resources. In Childhood Leukemias, Second Edition. Cambridge University Press. 2006. p. 625-638 https://doi.org/10.1017/CBO9780511471001.025
Ribeiro, Raul C. ; Howard, Scott ; Pui, Ching Hon. / Acute leukemia in countries with limited resources. Childhood Leukemias, Second Edition. Cambridge University Press, 2006. pp. 625-638
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