Acute optic neuritis associated with immunization with the CNS myelin proteolipid protein

Nicholas Potter, P. E. Bigazzi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Optic nerve tissue from SJL/J mice immunized with the central nervous system (CNS) myelin-specific proteolipid protein (PLP) was examined for histopathologic evidence of optic neuritis. Optic nerves isolated 17 d after immunization with PLP revealed an interstitial and submeningeal inflammatory infiltrate consisting of neutrophils and monocytes. In all cases, histologic evidence of optic nerve involvement correlated serologically with the presence of circulating anti-PLP antibodies. Control animals had no histopathologic evidence of disease or anti-PLP antibody. In many respects, the observed histopathologic profile of PLP-induced optic neuritis is similar to that associated with human inflammatory demyelinating diseases such as multiple sclerosis (MS). Because optic neuritis frequently is associated with some of the earliest clinical symptoms of MS, the acute nature of optic nerve involvement in this animal model suggests that immune recognition of the myelin PLP may play a significant role in the pathophysiology of optic nerve damage associated with sensitization to CNS-specific antigens.

Original languageEnglish (US)
Pages (from-to)1717-1722
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume33
Issue number5
StatePublished - May 11 1992
Externally publishedYes

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Myelin Proteolipid Protein
Optic Neuritis
Proteolipids
Optic Nerve
Immunization
Central Nervous System
Multiple Sclerosis
Proteins
Central Nervous System Sensitization
Nerve Tissue
Antibodies
Demyelinating Diseases
Monocytes
Neutrophils
Animal Models
Antigens

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Acute optic neuritis associated with immunization with the CNS myelin proteolipid protein. / Potter, Nicholas; Bigazzi, P. E.

In: Investigative Ophthalmology and Visual Science, Vol. 33, No. 5, 11.05.1992, p. 1717-1722.

Research output: Contribution to journalArticle

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