Adaptive-outward and maladaptive-inward arterial remodeling measured by intravascular ultrasound in hyperhomocysteinemia and diabetes

Hanumanth K. Reddy, Santhosh Koshy, Sanjeev Wasson, Edwin E. Quan, Sebastian Pagni, Andrew M. Roberts, Irving G. Joshua, Suresh C. Tyagi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Coronary artery remodeling implies structural changes in the vessel wall in response to various pathophysiologic conditions. However, the classification of remodeling is unclear. We hypothesized that the adaptive, positive-outward remodeling is a reactive and compensatory response to the stress. The maladaptive negative-inward constrictive remodeling is a passive atherosclerotic condition in which the vessel becomes stiffer. Methods: Patients with atherosclerotic lesions underwent intravascular ultrasound (IVUS) scans. The size of the vessels distal to and proximal to plaques were analyzed by IVUS. Diabetes was created in mice by an intraperitoneal injection of alloxan (65 mg/kg). To reduce remodeling, mice received ciglitazone, an agonist of peroxisome proliferators activated receptor-γ (PPARγ) in drinking water. After 8 weeks, atherosclerotic vessels were analyzed for collagen and elastin. Results: IVUS data suggest an adaptive coronary arterial remodeling was a positive compensatory response to various pathologic stimuli; for example, with the deposition of atherosclerotic plaque, coronary arterial segments enlarged to maintain luminal area. This phenomenon was commonly observed during the initial phases of the development of atherosclerosis. However, negative coronary artery remodeling, or a decrease in vessel area with the formation of atherosclerotic plaque, was maladaptive and was associated with smoking, hypertension, hyperhomocysteinemia, diabetes mellitus, and also after percutaneous coronary interventions (restenosis). In diabetic mice, there was increased collagen and decreased elastin contents; however, treatment with ciglitazone ameliorated the decrease in elastin contents. Conclusion: Global enlargement of the coronary vascular tree occurs during pressure and volume overload associated with ventricular hypertrophic states such as athletic conditioning, hypertensive heart disease, and dilated cardiomyopathy. On the other hand, maladaptive coronary arterial remodeling occurs in patients with severe deconditioning, diabetes mellitus, after coronary artery bypass surgery, and in some instances, postintervention.

Original languageEnglish (US)
Pages (from-to)65-76
Number of pages12
JournalJournal of Cardiovascular Pharmacology and Therapeutics
Volume11
Issue number1
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

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Hyperhomocysteinemia
Elastin
Atherosclerotic Plaques
Coronary Vessels
Diabetes Mellitus
Collagen
Coronary Restenosis
Alloxan
Peroxisome Proliferator-Activated Receptors
Dilated Cardiomyopathy
Percutaneous Coronary Intervention
Intraperitoneal Injections
Coronary Artery Bypass
Drinking Water
Sports
Blood Vessels
Heart Diseases
Atherosclerosis
Smoking
Hypertension

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

Adaptive-outward and maladaptive-inward arterial remodeling measured by intravascular ultrasound in hyperhomocysteinemia and diabetes. / Reddy, Hanumanth K.; Koshy, Santhosh; Wasson, Sanjeev; Quan, Edwin E.; Pagni, Sebastian; Roberts, Andrew M.; Joshua, Irving G.; Tyagi, Suresh C.

In: Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 11, No. 1, 01.03.2006, p. 65-76.

Research output: Contribution to journalArticle

Reddy, Hanumanth K. ; Koshy, Santhosh ; Wasson, Sanjeev ; Quan, Edwin E. ; Pagni, Sebastian ; Roberts, Andrew M. ; Joshua, Irving G. ; Tyagi, Suresh C. / Adaptive-outward and maladaptive-inward arterial remodeling measured by intravascular ultrasound in hyperhomocysteinemia and diabetes. In: Journal of Cardiovascular Pharmacology and Therapeutics. 2006 ; Vol. 11, No. 1. pp. 65-76.
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AU - Koshy, Santhosh

AU - Wasson, Sanjeev

AU - Quan, Edwin E.

AU - Pagni, Sebastian

AU - Roberts, Andrew M.

AU - Joshua, Irving G.

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