Adaptive radiation therapy for head and neck cancer-can an old goal evolve into a new standard?

David Schwartz, Lei Dong

Research output: Contribution to journalReview article

39 Citations (Scopus)

Abstract

Current head and neck intensity-modulated radiotherapy (IMRT) techniques cause significant toxicity. This may be explained in part by the fact that IMRT cannot compensate for changes in the location of disease and normal anatomy during treatment, leading to exposure of at-risk bystander tissues to higher-than-anticipated doses. Adaptive radiotherapy (ART) is a novel approach to correct for daily tumor and normal tissue variations through online or offline modification of original IMRT target volumes and plans. ART has been discussed on a conceptual level for many years, but technical limitations have hampered its integration into routine care. In this paper, we review the key anatomic, dosimetric, and treatment delivery issues at play in current investigational development of head and neck ART. We also describe pilot findings from initial clinical deployment of head and neck ART, as well as emerging pathways of future research.

Original languageEnglish (US)
Article number690595
JournalJournal of Oncology
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

Fingerprint

Head and Neck Neoplasms
Intensity-Modulated Radiotherapy
Radiotherapy
Neck
Head
Anatomy
Therapeutics
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Adaptive radiation therapy for head and neck cancer-can an old goal evolve into a new standard? / Schwartz, David; Dong, Lei.

In: Journal of Oncology, 01.01.2011.

Research output: Contribution to journalReview article

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