Adenoviral vector-mediated rescue of the OMP-null behavioral phenotype

Enhancement of odorant threshold sensitivity

Steven Youngentob, Martina M. Pyrski, Frank L. Margolis

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Mice from which the olfactory marker protein (OMP) gene has been deleted demonstrate a number of neurophysiologic and behavioral defects that suggest OMP is an important component in olfactory signal transduction and is critically involved in odor processing. Recently, the potential pleiotropic effects of gene deletion were addressed by adenoviral vector-mediated rescue of the neurophysiologic defects, in vivo. As a complement to this study, the authors used a recombinant adenoviral vector to transiently introduce OMP into olfactory sensory neurons of adult OMP-null mice and, using psychophysical methods, demonstrated the resulting reacquisition of behavioral function subsequent to gene replacement. The rescue of the OMP-null behavioral phenotype further supports the hypothesis that OMP is an important component in olfactory signal amplification and/or transduction processing.

Original languageEnglish (US)
Pages (from-to)636-642
Number of pages7
JournalBehavioral Neuroscience
Volume118
Issue number3
DOIs
StatePublished - Jun 2004
Externally publishedYes

Fingerprint

Olfactory Marker Protein
Phenotype
Genetic Pleiotropy
Olfactory Receptor Neurons
Gene Deletion
Genes
Signal Transduction
Odorants

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Adenoviral vector-mediated rescue of the OMP-null behavioral phenotype : Enhancement of odorant threshold sensitivity. / Youngentob, Steven; Pyrski, Martina M.; Margolis, Frank L.

In: Behavioral Neuroscience, Vol. 118, No. 3, 06.2004, p. 636-642.

Research output: Contribution to journalArticle

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