Adjunctive and alternative approaches to current reperfusion therapy

Andrew D. Barreto, Andrei Alexandrov

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background and Purpose-: Current ischemic stroke reperfusion therapy consists of intravenous thrombolysis given in eligible patients after review of a noncontrast CT scan and a time-based window of opportunity. Rapid clot lysis has a strong association with clinical improvement but remains incomplete in many patients. This review appraises novel adjunctive or alternative approaches to current reperfusion strategies being tested in all trial phases. SUMMARY OF REVIEW-: Alternative approaches to current reperfusion therapy can be separated into 4 main categories: (1) combinatory approaches with other drugs or devices; (2) novel systemic thrombolytic agents; (3) endovascular medical or mechanical reperfusion treatments; and (4) noninvasive or minimally invasive Methods to augment cerebral blood flow and alleviate intracranial blood flow steal. Conclusions-: Reperfusion treatments must be provided as fast as possible in patients most likely to benefit. Patients who fail to rapidly reperfuse may benefit from other strategies that maintain collateral flow or protect tissue at risk.

Original languageEnglish (US)
Pages (from-to)591-598
Number of pages8
JournalStroke
Volume43
Issue number2
DOIs
StatePublished - Feb 1 2012

Fingerprint

Reperfusion
Cerebrovascular Circulation
Therapeutics
Fibrinolytic Agents
Stroke
Equipment and Supplies
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Adjunctive and alternative approaches to current reperfusion therapy. / Barreto, Andrew D.; Alexandrov, Andrei.

In: Stroke, Vol. 43, No. 2, 01.02.2012, p. 591-598.

Research output: Contribution to journalArticle

Barreto, Andrew D. ; Alexandrov, Andrei. / Adjunctive and alternative approaches to current reperfusion therapy. In: Stroke. 2012 ; Vol. 43, No. 2. pp. 591-598.
@article{f1bfd4b212794810a121ce26c512d897,
title = "Adjunctive and alternative approaches to current reperfusion therapy",
abstract = "Background and Purpose-: Current ischemic stroke reperfusion therapy consists of intravenous thrombolysis given in eligible patients after review of a noncontrast CT scan and a time-based window of opportunity. Rapid clot lysis has a strong association with clinical improvement but remains incomplete in many patients. This review appraises novel adjunctive or alternative approaches to current reperfusion strategies being tested in all trial phases. SUMMARY OF REVIEW-: Alternative approaches to current reperfusion therapy can be separated into 4 main categories: (1) combinatory approaches with other drugs or devices; (2) novel systemic thrombolytic agents; (3) endovascular medical or mechanical reperfusion treatments; and (4) noninvasive or minimally invasive Methods to augment cerebral blood flow and alleviate intracranial blood flow steal. Conclusions-: Reperfusion treatments must be provided as fast as possible in patients most likely to benefit. Patients who fail to rapidly reperfuse may benefit from other strategies that maintain collateral flow or protect tissue at risk.",
author = "Barreto, {Andrew D.} and Andrei Alexandrov",
year = "2012",
month = "2",
day = "1",
doi = "10.1161/STROKEAHA.111.617902",
language = "English (US)",
volume = "43",
pages = "591--598",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Adjunctive and alternative approaches to current reperfusion therapy

AU - Barreto, Andrew D.

AU - Alexandrov, Andrei

PY - 2012/2/1

Y1 - 2012/2/1

N2 - Background and Purpose-: Current ischemic stroke reperfusion therapy consists of intravenous thrombolysis given in eligible patients after review of a noncontrast CT scan and a time-based window of opportunity. Rapid clot lysis has a strong association with clinical improvement but remains incomplete in many patients. This review appraises novel adjunctive or alternative approaches to current reperfusion strategies being tested in all trial phases. SUMMARY OF REVIEW-: Alternative approaches to current reperfusion therapy can be separated into 4 main categories: (1) combinatory approaches with other drugs or devices; (2) novel systemic thrombolytic agents; (3) endovascular medical or mechanical reperfusion treatments; and (4) noninvasive or minimally invasive Methods to augment cerebral blood flow and alleviate intracranial blood flow steal. Conclusions-: Reperfusion treatments must be provided as fast as possible in patients most likely to benefit. Patients who fail to rapidly reperfuse may benefit from other strategies that maintain collateral flow or protect tissue at risk.

AB - Background and Purpose-: Current ischemic stroke reperfusion therapy consists of intravenous thrombolysis given in eligible patients after review of a noncontrast CT scan and a time-based window of opportunity. Rapid clot lysis has a strong association with clinical improvement but remains incomplete in many patients. This review appraises novel adjunctive or alternative approaches to current reperfusion strategies being tested in all trial phases. SUMMARY OF REVIEW-: Alternative approaches to current reperfusion therapy can be separated into 4 main categories: (1) combinatory approaches with other drugs or devices; (2) novel systemic thrombolytic agents; (3) endovascular medical or mechanical reperfusion treatments; and (4) noninvasive or minimally invasive Methods to augment cerebral blood flow and alleviate intracranial blood flow steal. Conclusions-: Reperfusion treatments must be provided as fast as possible in patients most likely to benefit. Patients who fail to rapidly reperfuse may benefit from other strategies that maintain collateral flow or protect tissue at risk.

UR - http://www.scopus.com/inward/record.url?scp=84856499792&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856499792&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.111.617902

DO - 10.1161/STROKEAHA.111.617902

M3 - Article

C2 - 22223237

AN - SCOPUS:84856499792

VL - 43

SP - 591

EP - 598

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 2

ER -