Administering human adipose-derived mesenchymal stem cells to prevent and treat experimental arthritis

Bin Zhou, Jingdong Yuan, Yixuan Zhou, Maher Ghawji, Yunping Deng, Austin J. Lee, Albert J. Lee, Usha Nair, Andrew Kang, David Brand, Tai June Yoo

Research output: Contribution to journalArticle

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Abstract

Rheumatoid arthritis is a chronic autoimmune disease and affecting approximately 1% of the population. Human adipose-derived mesenchymal stem cells (hASCs) were recently found to suppress effector T cell and inflammatory responses and, thus, to have beneficial effects in various autoimmune diseases. In this study, we examined whether hASCs could play a protective and/or therapeutic role in collagen-induced arthritis (CIA). We showed that hASCs both prevented and treated CIA by significantly reducing the incidence and severity of experimental arthritis. We further demonstrated that treatment with hASCs inhibited the production of various inflammatory mediators, decreased antigen-specific Th1/Th17 cell expansion, and induced the production of anti-inflammatory cytokine interleukin-10. Moreover, hASCs could induce the generation of antigen-specific Treg cells with the capacity to suppress collagen-specific T cell responses.

Original languageEnglish (US)
Pages (from-to)328-337
Number of pages10
JournalClinical Immunology
Volume141
Issue number3
DOIs
StatePublished - Dec 1 2011

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Experimental Arthritis
Mesenchymal Stromal Cells
Autoimmune Diseases
T-Lymphocytes
Th17 Cells
Antigens
Th1 Cells
Regulatory T-Lymphocytes
Interleukin-10
Rheumatoid Arthritis
Chronic Disease
Anti-Inflammatory Agents
Collagen
Cytokines
Incidence
Population

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Administering human adipose-derived mesenchymal stem cells to prevent and treat experimental arthritis. / Zhou, Bin; Yuan, Jingdong; Zhou, Yixuan; Ghawji, Maher; Deng, Yunping; Lee, Austin J.; Lee, Albert J.; Nair, Usha; Kang, Andrew; Brand, David; Yoo, Tai June.

In: Clinical Immunology, Vol. 141, No. 3, 01.12.2011, p. 328-337.

Research output: Contribution to journalArticle

Zhou, Bin ; Yuan, Jingdong ; Zhou, Yixuan ; Ghawji, Maher ; Deng, Yunping ; Lee, Austin J. ; Lee, Albert J. ; Nair, Usha ; Kang, Andrew ; Brand, David ; Yoo, Tai June. / Administering human adipose-derived mesenchymal stem cells to prevent and treat experimental arthritis. In: Clinical Immunology. 2011 ; Vol. 141, No. 3. pp. 328-337.
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