Administration of CD34 + cells after stroke enhances neurogenesis via angiogenesis in a mouse model

Akihiko Taguchi, Toshihiro Soma, Hidekazu Tanaka, Takayoshi Kanda, Hiroyuki Nishimura, Hiroo Yoshikawa, Yoshitane Tsukamoto, Hiroyuki Iso, Yoshihiro Fujimori, David Stern, Hiroaki Naritomi, Tomohiro Matsuyama

Research output: Contribution to journalArticle

639 Citations (Scopus)

Abstract

Thrombo-occlusive cerebrovascular disease resulting in stroke and permanent neuronal loss is an important cause of morbidity and mortality. Because of the unique properties of cerebral vasculature and the limited reparative capability of neuronal tissue, it has been difficult to devise effective neuroprotective therapies in cerebral ischemia. Our results demonstrate that systemic administration of human cord blood-derived CD34 + cells to immunocompromised mice subjected to stroke 48 hours earlier induces neovascularization in the ischemic zone and provides a favorable environment for neuronal regeneration. Endogenous neurogenesis, suppressed by an antiangiogenic agent, is accelerated as a result of enhanced migration of neuronal progenitor cells to the damaged area, followed by their maturation and functional recovery. Our data suggest an essential role for CD34 + cells in promoting directly or indirectly an environment conducive to neovascularization of ischemic brain so that neuronal regeneration can proceed.

Original languageEnglish (US)
Pages (from-to)330-338
Number of pages9
JournalJournal of Clinical Investigation
Volume114
Issue number3
DOIs
StatePublished - Aug 1 2004
Externally publishedYes

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Neurogenesis
Regeneration
Stroke
Cerebrovascular Disorders
Angiogenesis Inhibitors
Brain Ischemia
Fetal Blood
Stem Cells
Morbidity
Mortality
Brain
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Taguchi, A., Soma, T., Tanaka, H., Kanda, T., Nishimura, H., Yoshikawa, H., ... Matsuyama, T. (2004). Administration of CD34 + cells after stroke enhances neurogenesis via angiogenesis in a mouse model Journal of Clinical Investigation, 114(3), 330-338. https://doi.org/10.1172/JCI200420622

Administration of CD34 + cells after stroke enhances neurogenesis via angiogenesis in a mouse model . / Taguchi, Akihiko; Soma, Toshihiro; Tanaka, Hidekazu; Kanda, Takayoshi; Nishimura, Hiroyuki; Yoshikawa, Hiroo; Tsukamoto, Yoshitane; Iso, Hiroyuki; Fujimori, Yoshihiro; Stern, David; Naritomi, Hiroaki; Matsuyama, Tomohiro.

In: Journal of Clinical Investigation, Vol. 114, No. 3, 01.08.2004, p. 330-338.

Research output: Contribution to journalArticle

Taguchi, A, Soma, T, Tanaka, H, Kanda, T, Nishimura, H, Yoshikawa, H, Tsukamoto, Y, Iso, H, Fujimori, Y, Stern, D, Naritomi, H & Matsuyama, T 2004, ' Administration of CD34 + cells after stroke enhances neurogenesis via angiogenesis in a mouse model ', Journal of Clinical Investigation, vol. 114, no. 3, pp. 330-338. https://doi.org/10.1172/JCI200420622
Taguchi, Akihiko ; Soma, Toshihiro ; Tanaka, Hidekazu ; Kanda, Takayoshi ; Nishimura, Hiroyuki ; Yoshikawa, Hiroo ; Tsukamoto, Yoshitane ; Iso, Hiroyuki ; Fujimori, Yoshihiro ; Stern, David ; Naritomi, Hiroaki ; Matsuyama, Tomohiro. / Administration of CD34 + cells after stroke enhances neurogenesis via angiogenesis in a mouse model In: Journal of Clinical Investigation. 2004 ; Vol. 114, No. 3. pp. 330-338.
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