Adrenal cancer

W. Bradford Carter, Jeremiah Deneve, John D. Tourtelot, Jamie T. Caracciolo, Sarah E. Hoffe, Michael D. Chuong, Howard S. Lilienfeld

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Adrenal cortical cancer (ACC) is a rare tumor with an incidence of 1-2 per million population. Although most are identified incidentally on cross-sectional imaging, timely identification and early surgical treatment is critical for optimized treatment outcomes. Sixty percent of ACC autonomously produced adrenal cortical hormones, primarily cortisol or androgens and often present with clinical syndromes such as Cushing's syndrome or virilization. Cross-sectional imaging provides the best assessment of malignant potential. Imaging characteristics of benign neoplasms include low-density lesions (Hounsfield units < 10 on noncontrast CT, size < 4 cm, homogeneity, and rapid washout of contrast. Lipid rich adenomas show signal suppression on chemical shift MRI and very low SUV uptake on PET imaging. Since most adrenal masses are found incidentally, metabolic screening for hormone production should be performed in all cases, including patients without clinical evidence of hormone excess. Surgical resection is indicated for adrenal lesions with suspicion of malignancy and/or those exhibiting autonomous hormone production. While minimally invasive techniques may be appropriate for smaller tumors, oncologic principles should be followed.

Original languageEnglish (US)
Title of host publicationEssentials and Updates in Urologic Oncology (2 Volume Set)
PublisherNova Science Publishers, Inc.
Pages683-710
Number of pages28
ISBN (Print)9781620816493
StatePublished - Dec 1 2012
Externally publishedYes

Fingerprint

Adrenal Gland Neoplasms
Hormones
Imaging techniques
Tumors
Neoplasms
Virilism
Cushing Syndrome
Chemical shift
Adenoma
Magnetic resonance imaging
Androgens
Hydrocortisone
Screening
Lipids
Incidence
Population

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Carter, W. B., Deneve, J., Tourtelot, J. D., Caracciolo, J. T., Hoffe, S. E., Chuong, M. D., & Lilienfeld, H. S. (2012). Adrenal cancer. In Essentials and Updates in Urologic Oncology (2 Volume Set) (pp. 683-710). Nova Science Publishers, Inc..

Adrenal cancer. / Carter, W. Bradford; Deneve, Jeremiah; Tourtelot, John D.; Caracciolo, Jamie T.; Hoffe, Sarah E.; Chuong, Michael D.; Lilienfeld, Howard S.

Essentials and Updates in Urologic Oncology (2 Volume Set). Nova Science Publishers, Inc., 2012. p. 683-710.

Research output: Chapter in Book/Report/Conference proceedingChapter

Carter, WB, Deneve, J, Tourtelot, JD, Caracciolo, JT, Hoffe, SE, Chuong, MD & Lilienfeld, HS 2012, Adrenal cancer. in Essentials and Updates in Urologic Oncology (2 Volume Set). Nova Science Publishers, Inc., pp. 683-710.
Carter WB, Deneve J, Tourtelot JD, Caracciolo JT, Hoffe SE, Chuong MD et al. Adrenal cancer. In Essentials and Updates in Urologic Oncology (2 Volume Set). Nova Science Publishers, Inc. 2012. p. 683-710
Carter, W. Bradford ; Deneve, Jeremiah ; Tourtelot, John D. ; Caracciolo, Jamie T. ; Hoffe, Sarah E. ; Chuong, Michael D. ; Lilienfeld, Howard S. / Adrenal cancer. Essentials and Updates in Urologic Oncology (2 Volume Set). Nova Science Publishers, Inc., 2012. pp. 683-710
@inbook{46ce63c68ba44aa5b107d60969827495,
title = "Adrenal cancer",
abstract = "Adrenal cortical cancer (ACC) is a rare tumor with an incidence of 1-2 per million population. Although most are identified incidentally on cross-sectional imaging, timely identification and early surgical treatment is critical for optimized treatment outcomes. Sixty percent of ACC autonomously produced adrenal cortical hormones, primarily cortisol or androgens and often present with clinical syndromes such as Cushing's syndrome or virilization. Cross-sectional imaging provides the best assessment of malignant potential. Imaging characteristics of benign neoplasms include low-density lesions (Hounsfield units < 10 on noncontrast CT, size < 4 cm, homogeneity, and rapid washout of contrast. Lipid rich adenomas show signal suppression on chemical shift MRI and very low SUV uptake on PET imaging. Since most adrenal masses are found incidentally, metabolic screening for hormone production should be performed in all cases, including patients without clinical evidence of hormone excess. Surgical resection is indicated for adrenal lesions with suspicion of malignancy and/or those exhibiting autonomous hormone production. While minimally invasive techniques may be appropriate for smaller tumors, oncologic principles should be followed.",
author = "Carter, {W. Bradford} and Jeremiah Deneve and Tourtelot, {John D.} and Caracciolo, {Jamie T.} and Hoffe, {Sarah E.} and Chuong, {Michael D.} and Lilienfeld, {Howard S.}",
year = "2012",
month = "12",
day = "1",
language = "English (US)",
isbn = "9781620816493",
pages = "683--710",
booktitle = "Essentials and Updates in Urologic Oncology (2 Volume Set)",
publisher = "Nova Science Publishers, Inc.",

}

TY - CHAP

T1 - Adrenal cancer

AU - Carter, W. Bradford

AU - Deneve, Jeremiah

AU - Tourtelot, John D.

AU - Caracciolo, Jamie T.

AU - Hoffe, Sarah E.

AU - Chuong, Michael D.

AU - Lilienfeld, Howard S.

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Adrenal cortical cancer (ACC) is a rare tumor with an incidence of 1-2 per million population. Although most are identified incidentally on cross-sectional imaging, timely identification and early surgical treatment is critical for optimized treatment outcomes. Sixty percent of ACC autonomously produced adrenal cortical hormones, primarily cortisol or androgens and often present with clinical syndromes such as Cushing's syndrome or virilization. Cross-sectional imaging provides the best assessment of malignant potential. Imaging characteristics of benign neoplasms include low-density lesions (Hounsfield units < 10 on noncontrast CT, size < 4 cm, homogeneity, and rapid washout of contrast. Lipid rich adenomas show signal suppression on chemical shift MRI and very low SUV uptake on PET imaging. Since most adrenal masses are found incidentally, metabolic screening for hormone production should be performed in all cases, including patients without clinical evidence of hormone excess. Surgical resection is indicated for adrenal lesions with suspicion of malignancy and/or those exhibiting autonomous hormone production. While minimally invasive techniques may be appropriate for smaller tumors, oncologic principles should be followed.

AB - Adrenal cortical cancer (ACC) is a rare tumor with an incidence of 1-2 per million population. Although most are identified incidentally on cross-sectional imaging, timely identification and early surgical treatment is critical for optimized treatment outcomes. Sixty percent of ACC autonomously produced adrenal cortical hormones, primarily cortisol or androgens and often present with clinical syndromes such as Cushing's syndrome or virilization. Cross-sectional imaging provides the best assessment of malignant potential. Imaging characteristics of benign neoplasms include low-density lesions (Hounsfield units < 10 on noncontrast CT, size < 4 cm, homogeneity, and rapid washout of contrast. Lipid rich adenomas show signal suppression on chemical shift MRI and very low SUV uptake on PET imaging. Since most adrenal masses are found incidentally, metabolic screening for hormone production should be performed in all cases, including patients without clinical evidence of hormone excess. Surgical resection is indicated for adrenal lesions with suspicion of malignancy and/or those exhibiting autonomous hormone production. While minimally invasive techniques may be appropriate for smaller tumors, oncologic principles should be followed.

UR - http://www.scopus.com/inward/record.url?scp=84895266561&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895266561&partnerID=8YFLogxK

M3 - Chapter

SN - 9781620816493

SP - 683

EP - 710

BT - Essentials and Updates in Urologic Oncology (2 Volume Set)

PB - Nova Science Publishers, Inc.

ER -