Adult living donor versus deceased donor liver transplantation

A 6-year single center experience

Daniel Maluf, Richard Todd Stravitz, Adrian H. Cotterell, Marc P. Posner, Mitsuru Nakatsuka, Richard K. Sterling, Velimir A. Luketic, Mitchell L. Shiffman, John M. Ham, Amadeo Marcos, Martha K. Behnke, Robert A. Fisher

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

No long-term (>3 years) prospective comparison of adult-to-adult living donor liver transplantation (A2ALLTx) to adult deceased donor liver transplantation (ADDLTx) has been reported. This is a prospective, IRB approved, 6-year comparison of A2ALLTX to ADDLTx. Data include: age, gender, ethnicity, primary liver disease, waiting time, pretransplant CTP/MELD score, cold ischemia time (CIT), perioperative mortality, acute and chronic rejection, graft and patient survival, charges and post-transplant complications. In 6 years, 202 ADDLTx (74.5%) and 69 A2ALLTx (25.5%) were performed at VCUHS. Hepatitis C virus (HCV) was the most common reason for transplantation in both groups (48.1% vs. 42%). Data regarding overall patient and graft survival, monetary charges and retransplantation rates were similar. Comparison of patient/graft survivals, retransplantation rates in patients with and without HCV were not statistically different. A2ALLTx patients had less acute rejection (11.5% vs. 23.9%) and more biliary complications (26.1% vs. 11.4%). Overall, A2ALLTx is as durable a liver replacement technique as the ADDLTx. Patients with A2ALLTx were younger, had lower MELD scores, less acute rejection and similar histological HCV recurrence. Biliary complications were more common in A2ALLTx but were not associated with increased graft loss compared to ADDLTx.

Original languageEnglish (US)
Pages (from-to)149-156
Number of pages8
JournalAmerican Journal of Transplantation
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2005

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Living Donors
Liver Transplantation
Tissue Donors
Graft Survival
Hepacivirus
Transplants
Cold Ischemia
Cytidine Triphosphate
Research Ethics Committees
Liver Diseases
Survival Rate
Transplantation
Recurrence
Mortality
Liver

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Maluf, D., Stravitz, R. T., Cotterell, A. H., Posner, M. P., Nakatsuka, M., Sterling, R. K., ... Fisher, R. A. (2005). Adult living donor versus deceased donor liver transplantation: A 6-year single center experience. American Journal of Transplantation, 5(1), 149-156. https://doi.org/10.1111/j.1600-6143.2004.00654.x

Adult living donor versus deceased donor liver transplantation : A 6-year single center experience. / Maluf, Daniel; Stravitz, Richard Todd; Cotterell, Adrian H.; Posner, Marc P.; Nakatsuka, Mitsuru; Sterling, Richard K.; Luketic, Velimir A.; Shiffman, Mitchell L.; Ham, John M.; Marcos, Amadeo; Behnke, Martha K.; Fisher, Robert A.

In: American Journal of Transplantation, Vol. 5, No. 1, 01.01.2005, p. 149-156.

Research output: Contribution to journalArticle

Maluf, D, Stravitz, RT, Cotterell, AH, Posner, MP, Nakatsuka, M, Sterling, RK, Luketic, VA, Shiffman, ML, Ham, JM, Marcos, A, Behnke, MK & Fisher, RA 2005, 'Adult living donor versus deceased donor liver transplantation: A 6-year single center experience', American Journal of Transplantation, vol. 5, no. 1, pp. 149-156. https://doi.org/10.1111/j.1600-6143.2004.00654.x
Maluf, Daniel ; Stravitz, Richard Todd ; Cotterell, Adrian H. ; Posner, Marc P. ; Nakatsuka, Mitsuru ; Sterling, Richard K. ; Luketic, Velimir A. ; Shiffman, Mitchell L. ; Ham, John M. ; Marcos, Amadeo ; Behnke, Martha K. ; Fisher, Robert A. / Adult living donor versus deceased donor liver transplantation : A 6-year single center experience. In: American Journal of Transplantation. 2005 ; Vol. 5, No. 1. pp. 149-156.
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