Advanced glycation end product receptor-mediated cellular dysfunction

Angelika Bierhaus, Per M. Humpert, David Stern, Bernd Arnold, Peter P. Nawroth

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Advanced glycation end products (AGEs), S100/calgranulins, and HMGB1 proteins supposedly play a pivotal role in diabetes mellitus and other chronic inflammatory diseases by promoting cellular dysfunction via binding to cellular surface receptors. Particularly, engagement of the receptor for AGEs (RAGE) has gained major attention because it converts short-lasting cellular activation in sustained cellular dysfunction. Consistently, blockade of ligand-RAGE interaction with soluble RAGE (sRAGE) suppresses chronic cellular activation and dysfunction in animal models of chronic diseases. RAGE-/- mice, however, demonstrate that the protection conferred by RAGE deficiency is lower than that mediated by sRAGE. Furthermore, RAGE-/- mice can be protected by sRAGE in certain settings of the adaptive immune response. This finding implies that abounding RAGE ligands overworking the RAGE pathway might also activate other receptors.

Original languageEnglish (US)
Pages (from-to)676-680
Number of pages5
JournalAnnals of the New York Academy of Sciences
Volume1043
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

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Chronic Disease
Chemical activation
Leukocyte L1 Antigen Complex
HMGB1 Protein
Ligands
Advanced Glycosylation End Products
S100 Proteins
Advanced Glycosylation End Product-Specific Receptor
Mouse
Activation
Adaptive Immunity
Medical problems
Diabetes Mellitus
Animals
Animal Models
Animal Model
Protein
Pathway
Convert
Interaction

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Advanced glycation end product receptor-mediated cellular dysfunction. / Bierhaus, Angelika; Humpert, Per M.; Stern, David; Arnold, Bernd; Nawroth, Peter P.

In: Annals of the New York Academy of Sciences, Vol. 1043, 01.01.2005, p. 676-680.

Research output: Contribution to journalArticle

Bierhaus, Angelika ; Humpert, Per M. ; Stern, David ; Arnold, Bernd ; Nawroth, Peter P. / Advanced glycation end product receptor-mediated cellular dysfunction. In: Annals of the New York Academy of Sciences. 2005 ; Vol. 1043. pp. 676-680.
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