Advancing age leads to predominance of inhibitory receptor expressing CD4 T cells

Rudragouda Channappanavar, Brandon S. Twardy, Pratima Krishna, Susmit Suvas

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Decline in CD4 T cell function is the hallmark of aging. In this study, we compared the proportion and absolute number of inhibitory receptor expressing splenic CD4 T cells in unprimed young (2 months) and aged (20 months) C57BL/6 mice. Our results showed a predominance of PD-1, ICOS and CTLA-4 expressing conventional and regulatory CD4 T cells in aged mice. Furthermore, the expression of these molecules was localized to memory but not naïve CD4 T cell subset. Since aging is associated with decline in naïve but accumulation of hyporesponsive memory phenotype (MP) CD4 T cell, we hypothesize that inhibitory receptors can account for the senescence noted in MP subset of CD4 T cell.

Original languageEnglish (US)
Pages (from-to)709-712
Number of pages4
JournalMechanisms of Ageing and Development
Volume130
Issue number10
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

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CD4 Antigens
T-Lymphocyte Subsets
T-Lymphocytes
Costimulatory and Inhibitory T-Cell Receptors
Phenotype
Regulatory T-Lymphocytes
Inbred C57BL Mouse

All Science Journal Classification (ASJC) codes

  • Aging
  • Developmental Biology

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Advancing age leads to predominance of inhibitory receptor expressing CD4 T cells. / Channappanavar, Rudragouda; Twardy, Brandon S.; Krishna, Pratima; Suvas, Susmit.

In: Mechanisms of Ageing and Development, Vol. 130, No. 10, 01.10.2009, p. 709-712.

Research output: Contribution to journalArticle

Channappanavar, Rudragouda ; Twardy, Brandon S. ; Krishna, Pratima ; Suvas, Susmit. / Advancing age leads to predominance of inhibitory receptor expressing CD4 T cells. In: Mechanisms of Ageing and Development. 2009 ; Vol. 130, No. 10. pp. 709-712.
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