Adverse reproductive outcomes in urban women with adeno-associated virus-2 infections in early pregnancy

F. Arechavaleta-Velasco, Luis Gomez Carbajal, Y. Ma, J. Zhao, C. M. McGrath, M. D. Sammel, D. B. Nelson, S. Parry

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

BACKGROUND: We demonstrated recently that adeno-associated virus-2 (AAV-2) DNA was detected significantly more frequently in placental trophoblast cells from cases of severe pre-eclampsia than from normal term deliveries. Here, we sought to determine if maternal AAV-2 infection early in pregnancy preceded adverse outcomes resulting from placental dysfunction. METHODS: We collected first trimester maternal serum samples and compared anti-AAV-2 IgM antibody levels (indicating primary infection or reactivation of latent AAV-2) between controls delivered at term (n = 106) and three groups of cases: spontaneous abortions (n = 34), spontaneous preterm deliveries (n = 24) and women with at least one outcome usually attributed to placental dysfunction, including pre-eclampsia, intrauterine growth restriction (IUGR) or stillbirth (n = 20). The seroprevalence of immunoglobulin G (IgG) antibodies against AAV-2 and IgM antibodies against viruses that promote AAV-2 replication [adenovirus and cytomegalovirus (CMV)] were also determined. RESULTS: First trimester maternal IgM seropositivity was 5.6 times more prevalent among pre-eclampsia/IUGR/ stillbirth cases (P = 0.0004) and 7.6 times more prevalent among preterm deliveries (P < 0.0001) than among controls. CMV and adenovirus IgM antibodies and chronic AAV-2 infections (IgG seropositivity) were not associated with adverse pregnancy outcomes. CONCLUSIONS: Primary or reactivated AAV-2 infection (maternal IgM seropositivity) early in pregnancy was associated with adverse reproductive outcomes associated with placental dysfunction, including pre-eclampsia, stillbirth and spontaneous preterm delivery.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalHuman Reproduction
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2008

Fingerprint

Dependovirus
Virus Diseases
Pregnancy
Immunoglobulin M
Pre-Eclampsia
Stillbirth
Mothers
Antibodies
First Pregnancy Trimester
Cytomegalovirus
Adenoviridae
Immunoglobulin G
Seroepidemiologic Studies
Trophoblasts
Spontaneous Abortion
Pregnancy Outcome
Virus Replication
Growth
Viruses
DNA

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Arechavaleta-Velasco, F., Gomez Carbajal, L., Ma, Y., Zhao, J., McGrath, C. M., Sammel, M. D., ... Parry, S. (2008). Adverse reproductive outcomes in urban women with adeno-associated virus-2 infections in early pregnancy. Human Reproduction, 23(1), 29-36. https://doi.org/10.1093/humrep/dem360

Adverse reproductive outcomes in urban women with adeno-associated virus-2 infections in early pregnancy. / Arechavaleta-Velasco, F.; Gomez Carbajal, Luis; Ma, Y.; Zhao, J.; McGrath, C. M.; Sammel, M. D.; Nelson, D. B.; Parry, S.

In: Human Reproduction, Vol. 23, No. 1, 01.01.2008, p. 29-36.

Research output: Contribution to journalArticle

Arechavaleta-Velasco, F, Gomez Carbajal, L, Ma, Y, Zhao, J, McGrath, CM, Sammel, MD, Nelson, DB & Parry, S 2008, 'Adverse reproductive outcomes in urban women with adeno-associated virus-2 infections in early pregnancy', Human Reproduction, vol. 23, no. 1, pp. 29-36. https://doi.org/10.1093/humrep/dem360
Arechavaleta-Velasco F, Gomez Carbajal L, Ma Y, Zhao J, McGrath CM, Sammel MD et al. Adverse reproductive outcomes in urban women with adeno-associated virus-2 infections in early pregnancy. Human Reproduction. 2008 Jan 1;23(1):29-36. https://doi.org/10.1093/humrep/dem360
Arechavaleta-Velasco, F. ; Gomez Carbajal, Luis ; Ma, Y. ; Zhao, J. ; McGrath, C. M. ; Sammel, M. D. ; Nelson, D. B. ; Parry, S. / Adverse reproductive outcomes in urban women with adeno-associated virus-2 infections in early pregnancy. In: Human Reproduction. 2008 ; Vol. 23, No. 1. pp. 29-36.
@article{7230f475ca0c47328647a4e81ee3d22c,
title = "Adverse reproductive outcomes in urban women with adeno-associated virus-2 infections in early pregnancy",
abstract = "BACKGROUND: We demonstrated recently that adeno-associated virus-2 (AAV-2) DNA was detected significantly more frequently in placental trophoblast cells from cases of severe pre-eclampsia than from normal term deliveries. Here, we sought to determine if maternal AAV-2 infection early in pregnancy preceded adverse outcomes resulting from placental dysfunction. METHODS: We collected first trimester maternal serum samples and compared anti-AAV-2 IgM antibody levels (indicating primary infection or reactivation of latent AAV-2) between controls delivered at term (n = 106) and three groups of cases: spontaneous abortions (n = 34), spontaneous preterm deliveries (n = 24) and women with at least one outcome usually attributed to placental dysfunction, including pre-eclampsia, intrauterine growth restriction (IUGR) or stillbirth (n = 20). The seroprevalence of immunoglobulin G (IgG) antibodies against AAV-2 and IgM antibodies against viruses that promote AAV-2 replication [adenovirus and cytomegalovirus (CMV)] were also determined. RESULTS: First trimester maternal IgM seropositivity was 5.6 times more prevalent among pre-eclampsia/IUGR/ stillbirth cases (P = 0.0004) and 7.6 times more prevalent among preterm deliveries (P < 0.0001) than among controls. CMV and adenovirus IgM antibodies and chronic AAV-2 infections (IgG seropositivity) were not associated with adverse pregnancy outcomes. CONCLUSIONS: Primary or reactivated AAV-2 infection (maternal IgM seropositivity) early in pregnancy was associated with adverse reproductive outcomes associated with placental dysfunction, including pre-eclampsia, stillbirth and spontaneous preterm delivery.",
author = "F. Arechavaleta-Velasco and {Gomez Carbajal}, Luis and Y. Ma and J. Zhao and McGrath, {C. M.} and Sammel, {M. D.} and Nelson, {D. B.} and S. Parry",
year = "2008",
month = "1",
day = "1",
doi = "10.1093/humrep/dem360",
language = "English (US)",
volume = "23",
pages = "29--36",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Adverse reproductive outcomes in urban women with adeno-associated virus-2 infections in early pregnancy

AU - Arechavaleta-Velasco, F.

AU - Gomez Carbajal, Luis

AU - Ma, Y.

AU - Zhao, J.

AU - McGrath, C. M.

AU - Sammel, M. D.

AU - Nelson, D. B.

AU - Parry, S.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - BACKGROUND: We demonstrated recently that adeno-associated virus-2 (AAV-2) DNA was detected significantly more frequently in placental trophoblast cells from cases of severe pre-eclampsia than from normal term deliveries. Here, we sought to determine if maternal AAV-2 infection early in pregnancy preceded adverse outcomes resulting from placental dysfunction. METHODS: We collected first trimester maternal serum samples and compared anti-AAV-2 IgM antibody levels (indicating primary infection or reactivation of latent AAV-2) between controls delivered at term (n = 106) and three groups of cases: spontaneous abortions (n = 34), spontaneous preterm deliveries (n = 24) and women with at least one outcome usually attributed to placental dysfunction, including pre-eclampsia, intrauterine growth restriction (IUGR) or stillbirth (n = 20). The seroprevalence of immunoglobulin G (IgG) antibodies against AAV-2 and IgM antibodies against viruses that promote AAV-2 replication [adenovirus and cytomegalovirus (CMV)] were also determined. RESULTS: First trimester maternal IgM seropositivity was 5.6 times more prevalent among pre-eclampsia/IUGR/ stillbirth cases (P = 0.0004) and 7.6 times more prevalent among preterm deliveries (P < 0.0001) than among controls. CMV and adenovirus IgM antibodies and chronic AAV-2 infections (IgG seropositivity) were not associated with adverse pregnancy outcomes. CONCLUSIONS: Primary or reactivated AAV-2 infection (maternal IgM seropositivity) early in pregnancy was associated with adverse reproductive outcomes associated with placental dysfunction, including pre-eclampsia, stillbirth and spontaneous preterm delivery.

AB - BACKGROUND: We demonstrated recently that adeno-associated virus-2 (AAV-2) DNA was detected significantly more frequently in placental trophoblast cells from cases of severe pre-eclampsia than from normal term deliveries. Here, we sought to determine if maternal AAV-2 infection early in pregnancy preceded adverse outcomes resulting from placental dysfunction. METHODS: We collected first trimester maternal serum samples and compared anti-AAV-2 IgM antibody levels (indicating primary infection or reactivation of latent AAV-2) between controls delivered at term (n = 106) and three groups of cases: spontaneous abortions (n = 34), spontaneous preterm deliveries (n = 24) and women with at least one outcome usually attributed to placental dysfunction, including pre-eclampsia, intrauterine growth restriction (IUGR) or stillbirth (n = 20). The seroprevalence of immunoglobulin G (IgG) antibodies against AAV-2 and IgM antibodies against viruses that promote AAV-2 replication [adenovirus and cytomegalovirus (CMV)] were also determined. RESULTS: First trimester maternal IgM seropositivity was 5.6 times more prevalent among pre-eclampsia/IUGR/ stillbirth cases (P = 0.0004) and 7.6 times more prevalent among preterm deliveries (P < 0.0001) than among controls. CMV and adenovirus IgM antibodies and chronic AAV-2 infections (IgG seropositivity) were not associated with adverse pregnancy outcomes. CONCLUSIONS: Primary or reactivated AAV-2 infection (maternal IgM seropositivity) early in pregnancy was associated with adverse reproductive outcomes associated with placental dysfunction, including pre-eclampsia, stillbirth and spontaneous preterm delivery.

UR - http://www.scopus.com/inward/record.url?scp=40549124961&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40549124961&partnerID=8YFLogxK

U2 - 10.1093/humrep/dem360

DO - 10.1093/humrep/dem360

M3 - Article

VL - 23

SP - 29

EP - 36

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 1

ER -