Aerosol delivery during mechanical ventilation: from basic techniques to new devices.

Research output: Contribution to journalReview article

106 Citations (Scopus)

Abstract

Pressurized metered-dose inhalers (pMDIs) and nebulizers are routinely employed for aerosol delivery in mechanically ventilated patients. A significant proportion of the aerosol deposits in the ventilator circuit and artificial airway, thereby reducing the inhaled drug mass. Factors influencing aerosol delivery during mechanical ventilation differ from those in spontaneously breathing patients. The English language literature on aerosol delivery during mechanical ventilation was reviewed. Marked variations in the efficiency of drug delivery with pMDIs and nebulizers occur due to differences in the technique of administration. Careful attention to five factors, viz., the aerosol generator, aerosol particle size, conditions in the ventilator circuit, artificial airway, and ventilator parameters, is necessary to optimize aerosol delivery during mechanical ventilation. Factors influencing drug delivery during NPPV are not well understood, and the efficiency of aerosol delivery in this setting is lower than that during invasive mechanical ventilaiton. With an optimal technique of administration the efficiency of aerosol delivery during mechanical ventilation is similar to that achieved during spontaneous breathing. Further research is needed to optimize aerosol delivery during NPPV.

Original languageEnglish (US)
Pages (from-to)45-60
Number of pages16
JournalJournal of aerosol medicine and pulmonary drug delivery
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Fingerprint

Aerosols
Artificial Respiration
Equipment and Supplies
Mechanical Ventilators
Metered Dose Inhalers
Nebulizers and Vaporizers
Respiration
Pharmaceutical Preparations
Particle Size
Language

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

Aerosol delivery during mechanical ventilation : from basic techniques to new devices. / Dhand, Rajiv.

In: Journal of aerosol medicine and pulmonary drug delivery, Vol. 21, No. 1, 01.01.2008, p. 45-60.

Research output: Contribution to journalReview article

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