Aerosol drug delivery

Developments in device design and clinical use

Myrna B. Dolovich, Rajiv Dhand

Research output: Contribution to journalReview article

227 Citations (Scopus)

Abstract

Aerosolised drugs are prescribed for use in a range of inhaler devices and systems. Delivering drugs by inhalation requires a formulation that can be successfully aerosolised and a delivery system that produces a useful aerosol of the drug; the particles or droplets need to be of sufficient size and mass to be carried to the distal lung or deposited on proximal airways to give rise to a therapeutic effect. Patients and caregivers must use and maintain these aerosol drug delivery devices correctly. In recent years, several technical innovations have led to aerosol drug delivery devices with efficient drug delivery and with novel features that take into account factors such as dose tracking, portability, materials of manufacture, breath actuation, the interface with the patient, combination therapies, and systemic delivery. These changes have improved performance in all four categories of devices: metered dose inhalers, spacers and holding chambers, dry powder inhalers, and nebulisers. Additionally, several therapies usually given by injection are now prescribed as aerosols for use in a range of drug delivery devices. In this Review, we discuss recent developments in the design and clinical use of aerosol devices over the past 10-15 years with an emphasis on the treatment of respiratory disorders.

Original languageEnglish (US)
Pages (from-to)1032-1045
Number of pages14
JournalThe Lancet
Volume377
Issue number9770
DOIs
StatePublished - Mar 19 2011
Externally publishedYes

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Equipment Design
Aerosols
Equipment and Supplies
Pharmaceutical Preparations
Nebulizers and Vaporizers
Inhalation Administration
Dry Powder Inhalers
Metered Dose Inhalers
Therapeutic Uses
Caregivers
Therapeutics
Lung
Injections

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Aerosol drug delivery : Developments in device design and clinical use. / Dolovich, Myrna B.; Dhand, Rajiv.

In: The Lancet, Vol. 377, No. 9770, 19.03.2011, p. 1032-1045.

Research output: Contribution to journalReview article

Dolovich, Myrna B. ; Dhand, Rajiv. / Aerosol drug delivery : Developments in device design and clinical use. In: The Lancet. 2011 ; Vol. 377, No. 9770. pp. 1032-1045.
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