Age and gender disparities in the risk of carotid revascularization procedures

Sotirios Giannopoulos, Aristeidis H. Katsanos, Spyros N. Vasdekis, Efstathios Boviatsis, Konstantinos I. Voumvourakis, Georgios Tsivgoulis

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

The potential effect of age and gender stratification in the outcome of patients with carotid artery stenosis undergoing carotid revascularization procedures (CRP) may have important implications in clinical practice. Both European Stroke Organization and American Heart Association guidelines suggest that age and sex should be taken into account when selecting a CRP for an individual patient. We reviewed available literature data through Medline and Embase. Our search was based on the combination of terms: age, gender, sex, carotid artery stenosis, carotid artery stenting (CAS) and carotid endarterectomy (CEA). Postoperative stroke and mortality rates increased with age after any CRP (CEA or CAS), especially in patients aged over 75 years. Older patients with carotid artery stenosis undergoing CAS were found to have a nearly double risk of stroke or death compared with CEA, while CEA was found to benefit more patients aged over 70 years with symptomatic carotid artery stenosis. Male patients with symptomatic or asymptomatic carotid artery stenosis had lower stroke/mortality rates and benefited more from CEA compared with females. For the periprocedural risk of stroke or death in patients with carotid artery stenosis after CAS no sex differences were found. Therefore, CEA appears to have lower perioperative risks than CAS in patients aged over 70 years, and thus should be the treatment of choice if not contraindicated. The periprocedural risk of CEA is lower in men than in women, while there was no effect of gender on the periprocedural risk of CAS.

Original languageEnglish (US)
Pages (from-to)1711-1717
Number of pages7
JournalNeurological Sciences
Volume34
Issue number10
DOIs
StatePublished - May 13 2013
Externally publishedYes

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Carotid Endarterectomy
Carotid Stenosis
Carotid Arteries
Stroke
Mortality
Sex Characteristics
Organizations
Guidelines

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Giannopoulos, S., Katsanos, A. H., Vasdekis, S. N., Boviatsis, E., Voumvourakis, K. I., & Tsivgoulis, G. (2013). Age and gender disparities in the risk of carotid revascularization procedures. Neurological Sciences, 34(10), 1711-1717. https://doi.org/10.1007/s10072-013-1453-2

Age and gender disparities in the risk of carotid revascularization procedures. / Giannopoulos, Sotirios; Katsanos, Aristeidis H.; Vasdekis, Spyros N.; Boviatsis, Efstathios; Voumvourakis, Konstantinos I.; Tsivgoulis, Georgios.

In: Neurological Sciences, Vol. 34, No. 10, 13.05.2013, p. 1711-1717.

Research output: Contribution to journalReview article

Giannopoulos, S, Katsanos, AH, Vasdekis, SN, Boviatsis, E, Voumvourakis, KI & Tsivgoulis, G 2013, 'Age and gender disparities in the risk of carotid revascularization procedures', Neurological Sciences, vol. 34, no. 10, pp. 1711-1717. https://doi.org/10.1007/s10072-013-1453-2
Giannopoulos S, Katsanos AH, Vasdekis SN, Boviatsis E, Voumvourakis KI, Tsivgoulis G. Age and gender disparities in the risk of carotid revascularization procedures. Neurological Sciences. 2013 May 13;34(10):1711-1717. https://doi.org/10.1007/s10072-013-1453-2
Giannopoulos, Sotirios ; Katsanos, Aristeidis H. ; Vasdekis, Spyros N. ; Boviatsis, Efstathios ; Voumvourakis, Konstantinos I. ; Tsivgoulis, Georgios. / Age and gender disparities in the risk of carotid revascularization procedures. In: Neurological Sciences. 2013 ; Vol. 34, No. 10. pp. 1711-1717.
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