Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11

Hui Chen Hsu, John D. Mountz, Robert Williams, Brent J. Shelton, Ping Ar Yang, Yasunori Matsuki, Xin Xu, Christopher H. Dodd, Lina Li, Hartmut Geiger, Huang Ge Zhang, Gary Van Zant

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Age-related decline in thymic T-cell development in 22-month-old C57BL/6J X DBA/2J (BXD) recombinant inbred strains of mice was functionally and phenotypically analyzed and genetically mapped. There was a positive correlation of the concanavalin A (Con A)-induced thymocyte proliferative response with the capability of thymocytes to mature to the CD4+CD8+ stage. The accumulation of CD4-CD8- stage of thymocytes in 22-month-old BXD mice was further identified to be associated with a developmental block between the CD25-CD44+ and the CD25+CD44+ stages. The quantitative trait loci regulating the Con A-induced thymocyte proliferative response were mapped to mouse chromosome 1, 3, and 11, nearest to 32.1 centimorgan (cM), 5.6 cM, and 18.0 cM, respectively. Our results suggest that several genetic loci regulate the intra-thymic T-cell maturation process and play an important role in determining age-related decline in thymic T-cell development.

Original languageEnglish (US)
Pages (from-to)1145-1158
Number of pages14
JournalMechanisms of Ageing and Development
Volume123
Issue number8
DOIs
StatePublished - Apr 30 2002

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Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 3
Genetic Loci
Chromosomes, Human, Pair 1
Thymocytes
T-Lymphocytes
Concanavalin A
Inbred Strains Mice
Quantitative Trait Loci

All Science Journal Classification (ASJC) codes

  • Aging
  • Developmental Biology

Cite this

Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11. / Hsu, Hui Chen; Mountz, John D.; Williams, Robert; Shelton, Brent J.; Yang, Ping Ar; Matsuki, Yasunori; Xu, Xin; Dodd, Christopher H.; Li, Lina; Geiger, Hartmut; Zhang, Huang Ge; Van Zant, Gary.

In: Mechanisms of Ageing and Development, Vol. 123, No. 8, 30.04.2002, p. 1145-1158.

Research output: Contribution to journalArticle

Hsu, HC, Mountz, JD, Williams, R, Shelton, BJ, Yang, PA, Matsuki, Y, Xu, X, Dodd, CH, Li, L, Geiger, H, Zhang, HG & Van Zant, G 2002, 'Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11', Mechanisms of Ageing and Development, vol. 123, no. 8, pp. 1145-1158. https://doi.org/10.1016/S0047-6374(02)00004-0
Hsu, Hui Chen ; Mountz, John D. ; Williams, Robert ; Shelton, Brent J. ; Yang, Ping Ar ; Matsuki, Yasunori ; Xu, Xin ; Dodd, Christopher H. ; Li, Lina ; Geiger, Hartmut ; Zhang, Huang Ge ; Van Zant, Gary. / Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11. In: Mechanisms of Ageing and Development. 2002 ; Vol. 123, No. 8. pp. 1145-1158.
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