Age-related Decline of Disc Rim Area in Visually Normal Subjects

Clark S. Tsai, Robert Ritch, Dong H. Shin, Jim Wan, Thomas Chi

Research output: Contribution to journalArticle

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Abstract

Optic disc parameters and axial lengths were measured in 81 visually normal young and elderly white adults (young [n = 41]: 27.2 ± 5.7 years versus elderly [n = 40]: 68.8 ± 8.4 years) using Rodenstock Optic Disc Analyzer and A-scan sonography. Axial lengths correlated positively with optic disc parameters (Spearman correlation analysis: rim area: P = 0.042, disc area: P = 0.052, and cup volume: P = 0.010). Older subjects had a shorter axial length (23.09 ± 1.02 mm) and smaller disc rim area (1.171 ± 0.338 mm 2) than younger subjects (23.60 ± 1.15 mm and 1.325 ± 0.314 mm2; Mann-Whitney U test: P = 0.011 and P = 0.013, respectively). While both axial length and disc rim area declined with age (0.011 mm and 0.003 mm2 per year; Spearman correlation analysis: P = 0.032 and P = 0.020, respectively), the cup-to-disc and rim area-to-disc area ratios appeared to remain relatively constant throughout adult life. The age-related decline of disc rim area is consistent with histologic evidence of age-related decline of ganglion cell axons. The rim area-to-disc area ratio seems less affected by age, and is thus a better parameter to isolate age-related change from disease-related change of optic nerve in a longitudinal follow-up of diseases involving the optic nerve head.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalOphthalmology
Volume99
Issue number1
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

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Optic Disk
Optic Nerve
Nonparametric Statistics
Ganglia
Axons
Young Adult
Ultrasonography

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Age-related Decline of Disc Rim Area in Visually Normal Subjects. / Tsai, Clark S.; Ritch, Robert; Shin, Dong H.; Wan, Jim; Chi, Thomas.

In: Ophthalmology, Vol. 99, No. 1, 01.01.1992, p. 29-35.

Research output: Contribution to journalArticle

Tsai, Clark S. ; Ritch, Robert ; Shin, Dong H. ; Wan, Jim ; Chi, Thomas. / Age-related Decline of Disc Rim Area in Visually Normal Subjects. In: Ophthalmology. 1992 ; Vol. 99, No. 1. pp. 29-35.
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