Age-related differences in urinary 11-dehydroxythromboxane B2 between infants, children, and adolescents: Another example of developmental hemostasis?

Charles D. Varnell, Stuart L. Goldstein, Donald L. Yee, Jun Teruya, Kirk E. Guyer, Shakeel Siddiqui, John Jefferies

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Our study was developed to ascertain reference ranges of 11-dehydrothromboxane B2 (11-dhTXB2) in the urine of healthy pediatric subjects. Urine samples were analyzed using the AspirinWorks™ assay that measures levels of 11-dehydrothromboxane B2. 128 individuals (2 months to 18 years) were identified as healthy and not receiving aspirin. When adjusted as picograms/milligrams urine creatinine, there was a negative correlation between age and level of 11-dehydrothromboxane B2 (P=0.0001). This study confirms a negative correlation between age and level of urinary 11-dehydrothromboxane B2 and provides a set of age-specific reference ranges.

Original languageEnglish (US)
Pages (from-to)2074-2076
Number of pages3
JournalPediatric Blood and Cancer
Volume61
Issue number11
DOIs
StatePublished - Nov 1 2014

Fingerprint

Hemostasis
Urine
Reference Values
Aspirin
Creatinine
Healthy Volunteers
Pediatrics
11-dehydro-thromboxane B2

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Age-related differences in urinary 11-dehydroxythromboxane B2 between infants, children, and adolescents : Another example of developmental hemostasis? / Varnell, Charles D.; Goldstein, Stuart L.; Yee, Donald L.; Teruya, Jun; Guyer, Kirk E.; Siddiqui, Shakeel; Jefferies, John.

In: Pediatric Blood and Cancer, Vol. 61, No. 11, 01.11.2014, p. 2074-2076.

Research output: Contribution to journalArticle

Varnell, Charles D. ; Goldstein, Stuart L. ; Yee, Donald L. ; Teruya, Jun ; Guyer, Kirk E. ; Siddiqui, Shakeel ; Jefferies, John. / Age-related differences in urinary 11-dehydroxythromboxane B2 between infants, children, and adolescents : Another example of developmental hemostasis?. In: Pediatric Blood and Cancer. 2014 ; Vol. 61, No. 11. pp. 2074-2076.
@article{41be09313882410c9b3d05545158b27b,
title = "Age-related differences in urinary 11-dehydroxythromboxane B2 between infants, children, and adolescents: Another example of developmental hemostasis?",
abstract = "Our study was developed to ascertain reference ranges of 11-dehydrothromboxane B2 (11-dhTXB2) in the urine of healthy pediatric subjects. Urine samples were analyzed using the AspirinWorks™ assay that measures levels of 11-dehydrothromboxane B2. 128 individuals (2 months to 18 years) were identified as healthy and not receiving aspirin. When adjusted as picograms/milligrams urine creatinine, there was a negative correlation between age and level of 11-dehydrothromboxane B2 (P=0.0001). This study confirms a negative correlation between age and level of urinary 11-dehydrothromboxane B2 and provides a set of age-specific reference ranges.",
author = "Varnell, {Charles D.} and Goldstein, {Stuart L.} and Yee, {Donald L.} and Jun Teruya and Guyer, {Kirk E.} and Shakeel Siddiqui and John Jefferies",
year = "2014",
month = "11",
day = "1",
doi = "10.1002/pbc.25089",
language = "English (US)",
volume = "61",
pages = "2074--2076",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "11",

}

TY - JOUR

T1 - Age-related differences in urinary 11-dehydroxythromboxane B2 between infants, children, and adolescents

T2 - Another example of developmental hemostasis?

AU - Varnell, Charles D.

AU - Goldstein, Stuart L.

AU - Yee, Donald L.

AU - Teruya, Jun

AU - Guyer, Kirk E.

AU - Siddiqui, Shakeel

AU - Jefferies, John

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Our study was developed to ascertain reference ranges of 11-dehydrothromboxane B2 (11-dhTXB2) in the urine of healthy pediatric subjects. Urine samples were analyzed using the AspirinWorks™ assay that measures levels of 11-dehydrothromboxane B2. 128 individuals (2 months to 18 years) were identified as healthy and not receiving aspirin. When adjusted as picograms/milligrams urine creatinine, there was a negative correlation between age and level of 11-dehydrothromboxane B2 (P=0.0001). This study confirms a negative correlation between age and level of urinary 11-dehydrothromboxane B2 and provides a set of age-specific reference ranges.

AB - Our study was developed to ascertain reference ranges of 11-dehydrothromboxane B2 (11-dhTXB2) in the urine of healthy pediatric subjects. Urine samples were analyzed using the AspirinWorks™ assay that measures levels of 11-dehydrothromboxane B2. 128 individuals (2 months to 18 years) were identified as healthy and not receiving aspirin. When adjusted as picograms/milligrams urine creatinine, there was a negative correlation between age and level of 11-dehydrothromboxane B2 (P=0.0001). This study confirms a negative correlation between age and level of urinary 11-dehydrothromboxane B2 and provides a set of age-specific reference ranges.

UR - http://www.scopus.com/inward/record.url?scp=84922669184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922669184&partnerID=8YFLogxK

U2 - 10.1002/pbc.25089

DO - 10.1002/pbc.25089

M3 - Article

C2 - 24803308

AN - SCOPUS:84922669184

VL - 61

SP - 2074

EP - 2076

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 11

ER -