Age-related reduction of beta-adrenoceptor sensitivity in rat heart occurs by multiple mechanisms

Tai-Hwang Fan, Shailesh P. Banerjee

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Myocardial responsiveness to catecholamines was evaluated by measuring isoproterenol-stimulated adenylate cyclase activities in myocardial particulate fractions from Fischer 344 rats of 3, 12, and 24 months of age. Dose-response curves of isoproterenol revealed a progressive increase in the activation constant (Kact) with advancing age. In addition, the maximal velocity (Vmax) for 12- and 24-month-old groups was about. 20-25% lower than for the 3-month-old group. Analysis of receptor-binding data and nonreceptor-mediated enzyme activities suggests that the age-related decrease in Vmax for isoproterenol may result from a loss of myocardial β-receptors, whereas the increase in Kact is probably due to a deficit in the postreceptor components of the receptor-cyclase complex.

Original languageEnglish (US)
Pages (from-to)373-380
Number of pages8
JournalGerontology
Volume31
Issue number6
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

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Isoproterenol
Adrenergic Receptors
Inbred F344 Rats
Adenylyl Cyclases
Catecholamines
Enzymes

All Science Journal Classification (ASJC) codes

  • Aging
  • Geriatrics and Gerontology

Cite this

Age-related reduction of beta-adrenoceptor sensitivity in rat heart occurs by multiple mechanisms. / Fan, Tai-Hwang; Banerjee, Shailesh P.

In: Gerontology, Vol. 31, No. 6, 01.01.1985, p. 373-380.

Research output: Contribution to journalArticle

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