Aging effect on post-recovery hypofusion and mortality following cardiac arrest and resuscitation in rats

Kui Xu, Michelle Puchowicz, Joseph C. Lamanna

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In this study we investigated the effect of aging on brain blood flow following transient global ischemia. Male Fisher rats (6 and 24 months old) underwent cardiac arrest (15 min) and resuscitation. Regional brain (cortex, hippocampus, brainstem and cerebellum) blood flow was measured in non-arrested rats and 1-h recovery rats using [14C] iodoantipyrene (IAP) autoradiography; the 4-day survival rate was determined in the two age groups. The pre-arrest baseline blood flows were similar in cortex, brainstem and cerebellum between the 6-month and the 24-month old rats; however, the baseline blood flow in hippocampus was significantly lower in the 24-month old group. At 1 h following cardiac arrest and resuscitation, both 6-month and 24-month groups had significantly lower blood flows in all regions than the pre-arrest baseline values; compared to the 6-month old group, the blood flow was significantly lower (about 40% lower) in all regions in the 24-month old group. The 4-day survival rate for the 6-month old rats was 50% (3/6) whereas none of the 24-month old rats (0/10) survived for 4 days. The data suggest that there is an increased vulnerability to brain ischemic-reperfusion injury in the aged rats; the degree of post-recovery hypoperfusion may contribute to the high mortality in the aged rats following cardiac arrest and resuscitation.

Original languageEnglish (US)
Title of host publicationOxygen Transport to Tissue XXXVII
PublisherSpringer New York LLC
Pages265-270
Number of pages6
ISBN (Print)9781493930227
DOIs
StatePublished - Jan 1 2016
Externally publishedYes
Event42nd Annual Meeting of International Society on Oxygen Transport to Tissue - London, United Kingdom
Duration: Jun 28 2014Jul 3 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume876
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Other

Other42nd Annual Meeting of International Society on Oxygen Transport to Tissue
CountryUnited Kingdom
CityLondon
Period6/28/147/3/14

Fingerprint

Resuscitation
Heart Arrest
Rats
Aging of materials
Recovery
Mortality
Blood
Brain
Cerebellum
Brain Stem
Hippocampus
Survival Rate
Blood Group Antigens
Reperfusion Injury
Autoradiography
Ischemia
Age Groups

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Xu, K., Puchowicz, M., & Lamanna, J. C. (2016). Aging effect on post-recovery hypofusion and mortality following cardiac arrest and resuscitation in rats. In Oxygen Transport to Tissue XXXVII (pp. 265-270). (Advances in Experimental Medicine and Biology; Vol. 876). Springer New York LLC. https://doi.org/10.1007/978-1-4939-3023-4_33

Aging effect on post-recovery hypofusion and mortality following cardiac arrest and resuscitation in rats. / Xu, Kui; Puchowicz, Michelle; Lamanna, Joseph C.

Oxygen Transport to Tissue XXXVII. Springer New York LLC, 2016. p. 265-270 (Advances in Experimental Medicine and Biology; Vol. 876).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Xu, K, Puchowicz, M & Lamanna, JC 2016, Aging effect on post-recovery hypofusion and mortality following cardiac arrest and resuscitation in rats. in Oxygen Transport to Tissue XXXVII. Advances in Experimental Medicine and Biology, vol. 876, Springer New York LLC, pp. 265-270, 42nd Annual Meeting of International Society on Oxygen Transport to Tissue, London, United Kingdom, 6/28/14. https://doi.org/10.1007/978-1-4939-3023-4_33
Xu K, Puchowicz M, Lamanna JC. Aging effect on post-recovery hypofusion and mortality following cardiac arrest and resuscitation in rats. In Oxygen Transport to Tissue XXXVII. Springer New York LLC. 2016. p. 265-270. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4939-3023-4_33
Xu, Kui ; Puchowicz, Michelle ; Lamanna, Joseph C. / Aging effect on post-recovery hypofusion and mortality following cardiac arrest and resuscitation in rats. Oxygen Transport to Tissue XXXVII. Springer New York LLC, 2016. pp. 265-270 (Advances in Experimental Medicine and Biology).
@inproceedings{fa95e89092ca49a7b21e0ef41bf932a1,
title = "Aging effect on post-recovery hypofusion and mortality following cardiac arrest and resuscitation in rats",
abstract = "In this study we investigated the effect of aging on brain blood flow following transient global ischemia. Male Fisher rats (6 and 24 months old) underwent cardiac arrest (15 min) and resuscitation. Regional brain (cortex, hippocampus, brainstem and cerebellum) blood flow was measured in non-arrested rats and 1-h recovery rats using [14C] iodoantipyrene (IAP) autoradiography; the 4-day survival rate was determined in the two age groups. The pre-arrest baseline blood flows were similar in cortex, brainstem and cerebellum between the 6-month and the 24-month old rats; however, the baseline blood flow in hippocampus was significantly lower in the 24-month old group. At 1 h following cardiac arrest and resuscitation, both 6-month and 24-month groups had significantly lower blood flows in all regions than the pre-arrest baseline values; compared to the 6-month old group, the blood flow was significantly lower (about 40{\%} lower) in all regions in the 24-month old group. The 4-day survival rate for the 6-month old rats was 50{\%} (3/6) whereas none of the 24-month old rats (0/10) survived for 4 days. The data suggest that there is an increased vulnerability to brain ischemic-reperfusion injury in the aged rats; the degree of post-recovery hypoperfusion may contribute to the high mortality in the aged rats following cardiac arrest and resuscitation.",
author = "Kui Xu and Michelle Puchowicz and Lamanna, {Joseph C.}",
year = "2016",
month = "1",
day = "1",
doi = "10.1007/978-1-4939-3023-4_33",
language = "English (US)",
isbn = "9781493930227",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "265--270",
booktitle = "Oxygen Transport to Tissue XXXVII",

}

TY - GEN

T1 - Aging effect on post-recovery hypofusion and mortality following cardiac arrest and resuscitation in rats

AU - Xu, Kui

AU - Puchowicz, Michelle

AU - Lamanna, Joseph C.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - In this study we investigated the effect of aging on brain blood flow following transient global ischemia. Male Fisher rats (6 and 24 months old) underwent cardiac arrest (15 min) and resuscitation. Regional brain (cortex, hippocampus, brainstem and cerebellum) blood flow was measured in non-arrested rats and 1-h recovery rats using [14C] iodoantipyrene (IAP) autoradiography; the 4-day survival rate was determined in the two age groups. The pre-arrest baseline blood flows were similar in cortex, brainstem and cerebellum between the 6-month and the 24-month old rats; however, the baseline blood flow in hippocampus was significantly lower in the 24-month old group. At 1 h following cardiac arrest and resuscitation, both 6-month and 24-month groups had significantly lower blood flows in all regions than the pre-arrest baseline values; compared to the 6-month old group, the blood flow was significantly lower (about 40% lower) in all regions in the 24-month old group. The 4-day survival rate for the 6-month old rats was 50% (3/6) whereas none of the 24-month old rats (0/10) survived for 4 days. The data suggest that there is an increased vulnerability to brain ischemic-reperfusion injury in the aged rats; the degree of post-recovery hypoperfusion may contribute to the high mortality in the aged rats following cardiac arrest and resuscitation.

AB - In this study we investigated the effect of aging on brain blood flow following transient global ischemia. Male Fisher rats (6 and 24 months old) underwent cardiac arrest (15 min) and resuscitation. Regional brain (cortex, hippocampus, brainstem and cerebellum) blood flow was measured in non-arrested rats and 1-h recovery rats using [14C] iodoantipyrene (IAP) autoradiography; the 4-day survival rate was determined in the two age groups. The pre-arrest baseline blood flows were similar in cortex, brainstem and cerebellum between the 6-month and the 24-month old rats; however, the baseline blood flow in hippocampus was significantly lower in the 24-month old group. At 1 h following cardiac arrest and resuscitation, both 6-month and 24-month groups had significantly lower blood flows in all regions than the pre-arrest baseline values; compared to the 6-month old group, the blood flow was significantly lower (about 40% lower) in all regions in the 24-month old group. The 4-day survival rate for the 6-month old rats was 50% (3/6) whereas none of the 24-month old rats (0/10) survived for 4 days. The data suggest that there is an increased vulnerability to brain ischemic-reperfusion injury in the aged rats; the degree of post-recovery hypoperfusion may contribute to the high mortality in the aged rats following cardiac arrest and resuscitation.

UR - http://www.scopus.com/inward/record.url?scp=84958544146&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958544146&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-3023-4_33

DO - 10.1007/978-1-4939-3023-4_33

M3 - Conference contribution

C2 - 26782221

AN - SCOPUS:84958544146

SN - 9781493930227

T3 - Advances in Experimental Medicine and Biology

SP - 265

EP - 270

BT - Oxygen Transport to Tissue XXXVII

PB - Springer New York LLC

ER -