Aging-related considerations when evaluating the forced expiratory volume in 1 second (FEV1) over time

Carlos A. Vaz Fragoso, Gail McAvay, Peter H. Van Ness, E. Metter, Luigi Ferrucci, H. Klar Yaggi, John Concato, Thomas M. Gill

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Forced expiratory volume in 1 second (FEV1) over time is commonly expressed in liters and percent predicted (%Pred), or alternatively in L/m3 and Z-scores-which approach is more clinically meaningful has not been evaluated. Because it uniquely accounts for the effect of aging on FEV1 and spirometric performance, we hypothesized that the Z-score approach is more clinically meaningful, based on associations between cardiopulmonary predictors and FEV1 over time. Methods: Using linear mixed-effects models and data from the Baltimore Longitudinal Study on Aging, including 501 white participants aged 40-95 who had completed at least three longitudinal spirometric assessments, we evaluated the associations between cardiopulmonary predictors (obesity, smoking status, hypertension, chronic bronchitis, diabetes mellitus, and myocardial infarction) and FEV1 over time, in liters, %Pred, L/m3, and Z-scores. Results: Mean baseline values for FEV1 were 3.240 L, 96.4%Pred, 0.621 L/m3, and -0.239 as a Z-score (40.6th percentile). The annual decline in FEV1 was 0.040 L, 0.234%Pred, 0.007 L/m3, and 0.008 Z-score units. Baseline age was associated with FEV1 over time in liters and L/m3 (p <.001), and included a time interaction for%Pred (p <.001), but was not associated with Z-scores (p=.933). The associations of cardiopulmonary predictors with FEV1 over time were all significant when using Z-scores (p <.05), but varied for other methods of expressing FEV1. Conclusion: A Z-score approach is more clinically meaningful when evaluating FEV1 over time, as it accounted for the effect of aging and was more frequently associated with multiple cardiopulmonary predictors.

Original languageEnglish (US)
Pages (from-to)929-934
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume71
Issue number7
DOIs
StatePublished - Jan 1 2016

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Forced Expiratory Volume
Baltimore
Chronic Bronchitis
Longitudinal Studies
Diabetes Mellitus
Obesity
Smoking
Myocardial Infarction
Hypertension
prednylidene

All Science Journal Classification (ASJC) codes

  • Aging
  • Geriatrics and Gerontology

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Aging-related considerations when evaluating the forced expiratory volume in 1 second (FEV1) over time. / Vaz Fragoso, Carlos A.; McAvay, Gail; Van Ness, Peter H.; Metter, E.; Ferrucci, Luigi; Yaggi, H. Klar; Concato, John; Gill, Thomas M.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 71, No. 7, 01.01.2016, p. 929-934.

Research output: Contribution to journalArticle

Vaz Fragoso, Carlos A. ; McAvay, Gail ; Van Ness, Peter H. ; Metter, E. ; Ferrucci, Luigi ; Yaggi, H. Klar ; Concato, John ; Gill, Thomas M. / Aging-related considerations when evaluating the forced expiratory volume in 1 second (FEV1) over time. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2016 ; Vol. 71, No. 7. pp. 929-934.
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abstract = "Background: Forced expiratory volume in 1 second (FEV1) over time is commonly expressed in liters and percent predicted ({\%}Pred), or alternatively in L/m3 and Z-scores-which approach is more clinically meaningful has not been evaluated. Because it uniquely accounts for the effect of aging on FEV1 and spirometric performance, we hypothesized that the Z-score approach is more clinically meaningful, based on associations between cardiopulmonary predictors and FEV1 over time. Methods: Using linear mixed-effects models and data from the Baltimore Longitudinal Study on Aging, including 501 white participants aged 40-95 who had completed at least three longitudinal spirometric assessments, we evaluated the associations between cardiopulmonary predictors (obesity, smoking status, hypertension, chronic bronchitis, diabetes mellitus, and myocardial infarction) and FEV1 over time, in liters, {\%}Pred, L/m3, and Z-scores. Results: Mean baseline values for FEV1 were 3.240 L, 96.4{\%}Pred, 0.621 L/m3, and -0.239 as a Z-score (40.6th percentile). The annual decline in FEV1 was 0.040 L, 0.234{\%}Pred, 0.007 L/m3, and 0.008 Z-score units. Baseline age was associated with FEV1 over time in liters and L/m3 (p <.001), and included a time interaction for{\%}Pred (p <.001), but was not associated with Z-scores (p=.933). The associations of cardiopulmonary predictors with FEV1 over time were all significant when using Z-scores (p <.05), but varied for other methods of expressing FEV1. Conclusion: A Z-score approach is more clinically meaningful when evaluating FEV1 over time, as it accounted for the effect of aging and was more frequently associated with multiple cardiopulmonary predictors.",
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T1 - Aging-related considerations when evaluating the forced expiratory volume in 1 second (FEV1) over time

AU - Vaz Fragoso, Carlos A.

AU - McAvay, Gail

AU - Van Ness, Peter H.

AU - Metter, E.

AU - Ferrucci, Luigi

AU - Yaggi, H. Klar

AU - Concato, John

AU - Gill, Thomas M.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: Forced expiratory volume in 1 second (FEV1) over time is commonly expressed in liters and percent predicted (%Pred), or alternatively in L/m3 and Z-scores-which approach is more clinically meaningful has not been evaluated. Because it uniquely accounts for the effect of aging on FEV1 and spirometric performance, we hypothesized that the Z-score approach is more clinically meaningful, based on associations between cardiopulmonary predictors and FEV1 over time. Methods: Using linear mixed-effects models and data from the Baltimore Longitudinal Study on Aging, including 501 white participants aged 40-95 who had completed at least three longitudinal spirometric assessments, we evaluated the associations between cardiopulmonary predictors (obesity, smoking status, hypertension, chronic bronchitis, diabetes mellitus, and myocardial infarction) and FEV1 over time, in liters, %Pred, L/m3, and Z-scores. Results: Mean baseline values for FEV1 were 3.240 L, 96.4%Pred, 0.621 L/m3, and -0.239 as a Z-score (40.6th percentile). The annual decline in FEV1 was 0.040 L, 0.234%Pred, 0.007 L/m3, and 0.008 Z-score units. Baseline age was associated with FEV1 over time in liters and L/m3 (p <.001), and included a time interaction for%Pred (p <.001), but was not associated with Z-scores (p=.933). The associations of cardiopulmonary predictors with FEV1 over time were all significant when using Z-scores (p <.05), but varied for other methods of expressing FEV1. Conclusion: A Z-score approach is more clinically meaningful when evaluating FEV1 over time, as it accounted for the effect of aging and was more frequently associated with multiple cardiopulmonary predictors.

AB - Background: Forced expiratory volume in 1 second (FEV1) over time is commonly expressed in liters and percent predicted (%Pred), or alternatively in L/m3 and Z-scores-which approach is more clinically meaningful has not been evaluated. Because it uniquely accounts for the effect of aging on FEV1 and spirometric performance, we hypothesized that the Z-score approach is more clinically meaningful, based on associations between cardiopulmonary predictors and FEV1 over time. Methods: Using linear mixed-effects models and data from the Baltimore Longitudinal Study on Aging, including 501 white participants aged 40-95 who had completed at least three longitudinal spirometric assessments, we evaluated the associations between cardiopulmonary predictors (obesity, smoking status, hypertension, chronic bronchitis, diabetes mellitus, and myocardial infarction) and FEV1 over time, in liters, %Pred, L/m3, and Z-scores. Results: Mean baseline values for FEV1 were 3.240 L, 96.4%Pred, 0.621 L/m3, and -0.239 as a Z-score (40.6th percentile). The annual decline in FEV1 was 0.040 L, 0.234%Pred, 0.007 L/m3, and 0.008 Z-score units. Baseline age was associated with FEV1 over time in liters and L/m3 (p <.001), and included a time interaction for%Pred (p <.001), but was not associated with Z-scores (p=.933). The associations of cardiopulmonary predictors with FEV1 over time were all significant when using Z-scores (p <.05), but varied for other methods of expressing FEV1. Conclusion: A Z-score approach is more clinically meaningful when evaluating FEV1 over time, as it accounted for the effect of aging and was more frequently associated with multiple cardiopulmonary predictors.

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