AHP's, HAP's and DAP's

How potassium currents regulate the excitability of rat supraoptic neurones

Peter Roper, Joseph Callaway, Talent Shevchenko, Ryoichi Teruyama, William Armstrong

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

We have constructed mathematical models of the electrical activity of two hypothalamic supraoptic neuro-secretory cell-types, and we support our models with new calcium imaging and in vitro electrophysiological data. These cells are neurones that project to the pituitary gland and secrete either of two hormones, oxytocin or vasopressin, into the blood from their axonal terminals. Oxytocin-secreting and vasopressin-secreting cells are closely related and physically they differ only subtly, however when physiologically stressed their discharge patterns are dramatically distinct. We first show how each potassium current contributes to the action-potentials and after-potentials observed in these cells, and we show how these after-potentials are correlated to intra-cellular calcium elevations. We then show how these currents regulate the excitability of these cells and consequently shape their discharge pattern.

Original languageEnglish (US)
Pages (from-to)367-389
Number of pages23
JournalJournal of Computational Neuroscience
Volume15
Issue number3
DOIs
StatePublished - Nov 1 2003

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Potassium
Neurons
Oxytocin
Vasopressins
Calcium
Cell Shape
Pituitary Gland
Action Potentials
Theoretical Models
Hormones

All Science Journal Classification (ASJC) codes

  • Sensory Systems
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

AHP's, HAP's and DAP's : How potassium currents regulate the excitability of rat supraoptic neurones. / Roper, Peter; Callaway, Joseph; Shevchenko, Talent; Teruyama, Ryoichi; Armstrong, William.

In: Journal of Computational Neuroscience, Vol. 15, No. 3, 01.11.2003, p. 367-389.

Research output: Contribution to journalArticle

Roper, Peter ; Callaway, Joseph ; Shevchenko, Talent ; Teruyama, Ryoichi ; Armstrong, William. / AHP's, HAP's and DAP's : How potassium currents regulate the excitability of rat supraoptic neurones. In: Journal of Computational Neuroscience. 2003 ; Vol. 15, No. 3. pp. 367-389.
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