Air pollution and lung function in minority youth with asthma in the GALA II (Genesenvironments and admixture in Latino Americans) and SAGE II (study of African Americans, asthma, genes, and environments) studies

Andreas M. Neophytou, Marquitta J. White, Sam S. Oh, Neeta Thakur, Joshua M. Galanter, Katherine K. Nishimura, Maria Pino-Yanes, Dara G. Torgerson, Christopher R. Gignoux, Celeste Eng, Elizabeth A. Nguyen, Donglei Hu, Angel C. Mak, Rajesh Kumar, Max A. Seibold, Adam Davis, Harold J. Farber, Kelley Meade, Pedro C. Avila, Denise Serebrisky & 14 others Michael A. Lenoir, Emerita Brigino-Buenaventura, William Rodriguez-Cintron, Kirsten Bibbins-Domingo, Shannon M. Thyne, L. Keoki Williams, Saunak Sen, Frank D. Gilliland, W. James Gauderman, Jose R. Rodriguez-Santana, Fred Lurmann, John R. Balmes, Ellen A. Eisen, Esteban G. Burchard

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Rationale: Adverse effects of exposures to ambient air pollution on lung function are well documented, but evidence in racial/ethnic minority children is lacking. Objectives: To assess the relationship between air pollution and lung function in minority children with asthma and possible modification by global genetic ancestry. Methods: The study population consisted of 1,449 Latino and 519 African American children with asthma from five different geographical regions in the mainland United States and Puerto Rico. We examined five pollutants (particulate matter <10 mm and <2.5 mm in diameter, ozone, nitrogen dioxide, and sulfur dioxide), derived from participant residential history and ambient air monitoring data, and assessed over several time windows. We fit generalized additive models for associations between pollutant exposures and lung function parameters and tested for interaction terms between exposures and genetic ancestry. Measurements and Main Results: A 5 mg/m3 increase in average lifetime particulate matter less than or equal to 2.5 mm in diameter exposure was associated with a 7.7% decrease in FEV1 (95% confidence interval =211.8 to 23.5%) in the overall study population. Global genetic ancestry did not appear to significantly modify these associations, but percent African ancestry was a significant predictor of lung function. Conclusions: Early-life particulate exposures were associated with reduced lung function in Latino and African American children with asthma. This is the first study to report an association between exposure to particulates and reduced lung function in minority children in which racial/ethnic status was measured by ancestry-informative markers.

Original languageEnglish (US)
Pages (from-to)1271-1280
Number of pages10
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume193
Issue number11
DOIs
StatePublished - Jun 1 2016

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Air Pollution
Hispanic Americans
African Americans
Asthma
Lung
Genes
Particulate Matter
Nitrogen Dioxide
Puerto Rico
Sulfur Dioxide
Ozone
Population
History
Air
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Air pollution and lung function in minority youth with asthma in the GALA II (Genesenvironments and admixture in Latino Americans) and SAGE II (study of African Americans, asthma, genes, and environments) studies. / Neophytou, Andreas M.; White, Marquitta J.; Oh, Sam S.; Thakur, Neeta; Galanter, Joshua M.; Nishimura, Katherine K.; Pino-Yanes, Maria; Torgerson, Dara G.; Gignoux, Christopher R.; Eng, Celeste; Nguyen, Elizabeth A.; Hu, Donglei; Mak, Angel C.; Kumar, Rajesh; Seibold, Max A.; Davis, Adam; Farber, Harold J.; Meade, Kelley; Avila, Pedro C.; Serebrisky, Denise; Lenoir, Michael A.; Brigino-Buenaventura, Emerita; Rodriguez-Cintron, William; Bibbins-Domingo, Kirsten; Thyne, Shannon M.; Keoki Williams, L.; Sen, Saunak; Gilliland, Frank D.; James Gauderman, W.; Rodriguez-Santana, Jose R.; Lurmann, Fred; Balmes, John R.; Eisen, Ellen A.; Burchard, Esteban G.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 193, No. 11, 01.06.2016, p. 1271-1280.

Research output: Contribution to journalArticle

Neophytou, AM, White, MJ, Oh, SS, Thakur, N, Galanter, JM, Nishimura, KK, Pino-Yanes, M, Torgerson, DG, Gignoux, CR, Eng, C, Nguyen, EA, Hu, D, Mak, AC, Kumar, R, Seibold, MA, Davis, A, Farber, HJ, Meade, K, Avila, PC, Serebrisky, D, Lenoir, MA, Brigino-Buenaventura, E, Rodriguez-Cintron, W, Bibbins-Domingo, K, Thyne, SM, Keoki Williams, L, Sen, S, Gilliland, FD, James Gauderman, W, Rodriguez-Santana, JR, Lurmann, F, Balmes, JR, Eisen, EA & Burchard, EG 2016, 'Air pollution and lung function in minority youth with asthma in the GALA II (Genesenvironments and admixture in Latino Americans) and SAGE II (study of African Americans, asthma, genes, and environments) studies', American Journal of Respiratory and Critical Care Medicine, vol. 193, no. 11, pp. 1271-1280. https://doi.org/10.1164/rccm.201508-1706OC
Neophytou, Andreas M. ; White, Marquitta J. ; Oh, Sam S. ; Thakur, Neeta ; Galanter, Joshua M. ; Nishimura, Katherine K. ; Pino-Yanes, Maria ; Torgerson, Dara G. ; Gignoux, Christopher R. ; Eng, Celeste ; Nguyen, Elizabeth A. ; Hu, Donglei ; Mak, Angel C. ; Kumar, Rajesh ; Seibold, Max A. ; Davis, Adam ; Farber, Harold J. ; Meade, Kelley ; Avila, Pedro C. ; Serebrisky, Denise ; Lenoir, Michael A. ; Brigino-Buenaventura, Emerita ; Rodriguez-Cintron, William ; Bibbins-Domingo, Kirsten ; Thyne, Shannon M. ; Keoki Williams, L. ; Sen, Saunak ; Gilliland, Frank D. ; James Gauderman, W. ; Rodriguez-Santana, Jose R. ; Lurmann, Fred ; Balmes, John R. ; Eisen, Ellen A. ; Burchard, Esteban G. / Air pollution and lung function in minority youth with asthma in the GALA II (Genesenvironments and admixture in Latino Americans) and SAGE II (study of African Americans, asthma, genes, and environments) studies. In: American Journal of Respiratory and Critical Care Medicine. 2016 ; Vol. 193, No. 11. pp. 1271-1280.
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title = "Air pollution and lung function in minority youth with asthma in the GALA II (Genesenvironments and admixture in Latino Americans) and SAGE II (study of African Americans, asthma, genes, and environments) studies",
abstract = "Rationale: Adverse effects of exposures to ambient air pollution on lung function are well documented, but evidence in racial/ethnic minority children is lacking. Objectives: To assess the relationship between air pollution and lung function in minority children with asthma and possible modification by global genetic ancestry. Methods: The study population consisted of 1,449 Latino and 519 African American children with asthma from five different geographical regions in the mainland United States and Puerto Rico. We examined five pollutants (particulate matter <10 mm and <2.5 mm in diameter, ozone, nitrogen dioxide, and sulfur dioxide), derived from participant residential history and ambient air monitoring data, and assessed over several time windows. We fit generalized additive models for associations between pollutant exposures and lung function parameters and tested for interaction terms between exposures and genetic ancestry. Measurements and Main Results: A 5 mg/m3 increase in average lifetime particulate matter less than or equal to 2.5 mm in diameter exposure was associated with a 7.7{\%} decrease in FEV1 (95{\%} confidence interval =211.8 to 23.5{\%}) in the overall study population. Global genetic ancestry did not appear to significantly modify these associations, but percent African ancestry was a significant predictor of lung function. Conclusions: Early-life particulate exposures were associated with reduced lung function in Latino and African American children with asthma. This is the first study to report an association between exposure to particulates and reduced lung function in minority children in which racial/ethnic status was measured by ancestry-informative markers.",
author = "Neophytou, {Andreas M.} and White, {Marquitta J.} and Oh, {Sam S.} and Neeta Thakur and Galanter, {Joshua M.} and Nishimura, {Katherine K.} and Maria Pino-Yanes and Torgerson, {Dara G.} and Gignoux, {Christopher R.} and Celeste Eng and Nguyen, {Elizabeth A.} and Donglei Hu and Mak, {Angel C.} and Rajesh Kumar and Seibold, {Max A.} and Adam Davis and Farber, {Harold J.} and Kelley Meade and Avila, {Pedro C.} and Denise Serebrisky and Lenoir, {Michael A.} and Emerita Brigino-Buenaventura and William Rodriguez-Cintron and Kirsten Bibbins-Domingo and Thyne, {Shannon M.} and {Keoki Williams}, L. and Saunak Sen and Gilliland, {Frank D.} and {James Gauderman}, W. and Rodriguez-Santana, {Jose R.} and Fred Lurmann and Balmes, {John R.} and Eisen, {Ellen A.} and Burchard, {Esteban G.}",
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TY - JOUR

T1 - Air pollution and lung function in minority youth with asthma in the GALA II (Genesenvironments and admixture in Latino Americans) and SAGE II (study of African Americans, asthma, genes, and environments) studies

AU - Neophytou, Andreas M.

AU - White, Marquitta J.

AU - Oh, Sam S.

AU - Thakur, Neeta

AU - Galanter, Joshua M.

AU - Nishimura, Katherine K.

AU - Pino-Yanes, Maria

AU - Torgerson, Dara G.

AU - Gignoux, Christopher R.

AU - Eng, Celeste

AU - Nguyen, Elizabeth A.

AU - Hu, Donglei

AU - Mak, Angel C.

AU - Kumar, Rajesh

AU - Seibold, Max A.

AU - Davis, Adam

AU - Farber, Harold J.

AU - Meade, Kelley

AU - Avila, Pedro C.

AU - Serebrisky, Denise

AU - Lenoir, Michael A.

AU - Brigino-Buenaventura, Emerita

AU - Rodriguez-Cintron, William

AU - Bibbins-Domingo, Kirsten

AU - Thyne, Shannon M.

AU - Keoki Williams, L.

AU - Sen, Saunak

AU - Gilliland, Frank D.

AU - James Gauderman, W.

AU - Rodriguez-Santana, Jose R.

AU - Lurmann, Fred

AU - Balmes, John R.

AU - Eisen, Ellen A.

AU - Burchard, Esteban G.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Rationale: Adverse effects of exposures to ambient air pollution on lung function are well documented, but evidence in racial/ethnic minority children is lacking. Objectives: To assess the relationship between air pollution and lung function in minority children with asthma and possible modification by global genetic ancestry. Methods: The study population consisted of 1,449 Latino and 519 African American children with asthma from five different geographical regions in the mainland United States and Puerto Rico. We examined five pollutants (particulate matter <10 mm and <2.5 mm in diameter, ozone, nitrogen dioxide, and sulfur dioxide), derived from participant residential history and ambient air monitoring data, and assessed over several time windows. We fit generalized additive models for associations between pollutant exposures and lung function parameters and tested for interaction terms between exposures and genetic ancestry. Measurements and Main Results: A 5 mg/m3 increase in average lifetime particulate matter less than or equal to 2.5 mm in diameter exposure was associated with a 7.7% decrease in FEV1 (95% confidence interval =211.8 to 23.5%) in the overall study population. Global genetic ancestry did not appear to significantly modify these associations, but percent African ancestry was a significant predictor of lung function. Conclusions: Early-life particulate exposures were associated with reduced lung function in Latino and African American children with asthma. This is the first study to report an association between exposure to particulates and reduced lung function in minority children in which racial/ethnic status was measured by ancestry-informative markers.

AB - Rationale: Adverse effects of exposures to ambient air pollution on lung function are well documented, but evidence in racial/ethnic minority children is lacking. Objectives: To assess the relationship between air pollution and lung function in minority children with asthma and possible modification by global genetic ancestry. Methods: The study population consisted of 1,449 Latino and 519 African American children with asthma from five different geographical regions in the mainland United States and Puerto Rico. We examined five pollutants (particulate matter <10 mm and <2.5 mm in diameter, ozone, nitrogen dioxide, and sulfur dioxide), derived from participant residential history and ambient air monitoring data, and assessed over several time windows. We fit generalized additive models for associations between pollutant exposures and lung function parameters and tested for interaction terms between exposures and genetic ancestry. Measurements and Main Results: A 5 mg/m3 increase in average lifetime particulate matter less than or equal to 2.5 mm in diameter exposure was associated with a 7.7% decrease in FEV1 (95% confidence interval =211.8 to 23.5%) in the overall study population. Global genetic ancestry did not appear to significantly modify these associations, but percent African ancestry was a significant predictor of lung function. Conclusions: Early-life particulate exposures were associated with reduced lung function in Latino and African American children with asthma. This is the first study to report an association between exposure to particulates and reduced lung function in minority children in which racial/ethnic status was measured by ancestry-informative markers.

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