Alcohol Acceptance, Preference, and Sensitivity in Mice. I. Quantitative Genetic Analysis Using BXD Recombinant Inbred Strains

Lawrence A. Rodriguez, Robert Plomin, David A. Blizard, Byron Jones, Gerald E. McClearn

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Although the recombinant inbred strain method was designed for molecular genetic analysis of linkage, it also provides powerful quantitative genetic analyses of heritability and genetic correlations. Measures of alcohol acceptance, alcohol preference, and hypnotic dose sensitivity (HDS) were assessed in 21 strains of mice from the BXD Rl series. Sex differences were found to be significant at a phenotypic level. However, heritability estimates for acceptance, preference, and HDS are similar in males and females. Heritability estimates for the three measures are ∼0.20 for acceptance and preference, and 0.10 for HDS. Analyses of genetic correlations reveal that acceptance and preference share some degree of genetic influence, although they mostly operate under different genetically mediated mechanisms. HDS did not show a significant genetic relationship to either acceptance or preference. Strong correlations were obtained when acceptance, preference, and HDS strain means were correlated across male and female recombinant inbreds, suggesting substantial genetic similarity across sexes.

Original languageEnglish (US)
Pages (from-to)1416-1422
Number of pages7
JournalAlcoholism: Clinical and Experimental Research
Volume18
Issue number6
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

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Hypnotics and Sedatives
Alcohols
Genetic Linkage
Sex Characteristics
Molecular Biology

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

Alcohol Acceptance, Preference, and Sensitivity in Mice. I. Quantitative Genetic Analysis Using BXD Recombinant Inbred Strains. / Rodriguez, Lawrence A.; Plomin, Robert; Blizard, David A.; Jones, Byron; McClearn, Gerald E.

In: Alcoholism: Clinical and Experimental Research, Vol. 18, No. 6, 01.01.1994, p. 1416-1422.

Research output: Contribution to journalArticle

Rodriguez, Lawrence A. ; Plomin, Robert ; Blizard, David A. ; Jones, Byron ; McClearn, Gerald E. / Alcohol Acceptance, Preference, and Sensitivity in Mice. I. Quantitative Genetic Analysis Using BXD Recombinant Inbred Strains. In: Alcoholism: Clinical and Experimental Research. 1994 ; Vol. 18, No. 6. pp. 1416-1422.
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