Alcohol consumption and premotor corpus callosum in older adults

Dimitrios Kapogiannis, Jason Kisser, Christos Davatzikos, Luigi Ferrucci, E. Metter, Susan M. Resnick

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Heavy alcohol consumption is toxic to the brain, especially to the frontal white matter (WM), but whether lesser amounts of alcohol negatively impact the brain WM is unclear. In this study, we examined the relationship between self-reported alcohol consumption and regional WM and grey matter (GM) volume in fifty-six men and thirty-seven women (70. +. - 7. years) cognitively intact participants of the Baltimore Longitudinal Study of Aging (BLSA) with no history of alcohol abuse. We used regional analysis of volumes examined in normalized space (RAVENS) maps methodology for WM and GM segmentation and normalization followed by voxel based morphometry (VBM) implemented in SPM8 to examine the cross-sectional association between alcohol consumption and regional WM (and, separately, GM) volume controlling for age, sex, smoking, blood pressure and dietary thiamine intake. WM VBM revealed that in men, but not in women, higher alcohol consumption was associated with lower volume in premotor frontal corpus callosum. This finding suggests that even moderate amounts of alcohol may be detrimental to corpus callosum and white matter integrity.

Original languageEnglish (US)
Pages (from-to)704-710
Number of pages7
JournalEuropean Neuropsychopharmacology
Volume22
Issue number10
DOIs
StatePublished - Oct 1 2012
Externally publishedYes

Fingerprint

Corpus Callosum
Alcohol Drinking
Alcohols
Baltimore
Poisons
Thiamine
Brain
White Matter
Alcoholism
Longitudinal Studies
Smoking
Blood Pressure
Gray Matter

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Biological Psychiatry
  • Neurology
  • Pharmacology

Cite this

Kapogiannis, D., Kisser, J., Davatzikos, C., Ferrucci, L., Metter, E., & Resnick, S. M. (2012). Alcohol consumption and premotor corpus callosum in older adults. European Neuropsychopharmacology, 22(10), 704-710. https://doi.org/10.1016/j.euroneuro.2012.02.003

Alcohol consumption and premotor corpus callosum in older adults. / Kapogiannis, Dimitrios; Kisser, Jason; Davatzikos, Christos; Ferrucci, Luigi; Metter, E.; Resnick, Susan M.

In: European Neuropsychopharmacology, Vol. 22, No. 10, 01.10.2012, p. 704-710.

Research output: Contribution to journalArticle

Kapogiannis, D, Kisser, J, Davatzikos, C, Ferrucci, L, Metter, E & Resnick, SM 2012, 'Alcohol consumption and premotor corpus callosum in older adults', European Neuropsychopharmacology, vol. 22, no. 10, pp. 704-710. https://doi.org/10.1016/j.euroneuro.2012.02.003
Kapogiannis, Dimitrios ; Kisser, Jason ; Davatzikos, Christos ; Ferrucci, Luigi ; Metter, E. ; Resnick, Susan M. / Alcohol consumption and premotor corpus callosum in older adults. In: European Neuropsychopharmacology. 2012 ; Vol. 22, No. 10. pp. 704-710.
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