Aldosteronism revisited

Perspectives on less well-recognized actions of aldosterone

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

Aldosterone is a mineralocorticoid with protean actions in both epithelial and nonepithelial cells. These include endocrine properties of circulating aldosterone that promote Na+ resorption at the expense of well-recognized K+ excretion and less well-recognized Mg 2+ excretion in classic target tissues: kidneys, colon, and sweat and salivary glands. The regulation of adrenal aldosterone secretion by [Mg 2+]o is also less well appreciated. More recently recognized endocrine actions of aldosterone include induction of Mg 2+ efflux in exchange for Na+ in such nonepithelial cells as peripheral-blood mononuclear cells and influence on epithelial cells of the choroid plexus, where aldosterone alters the composition of cerebrospinal fluid that contributes to blood-pressure regulation. An association between primary aldosteronism and idiopathic intracranial hypertension has recently been reported. Extraadrenal steroidogenesis with de novo aldosterone production by the cardiovasculature, where its auto-/paracrine properties may contribute to tissue repair at sites of injury, has been observed. These less well-recognized actions of aldosterone have led to a revival of interest in how this steroid molecule contributes to the pathophysiology of various clinical disorders.

Original languageEnglish (US)
Pages (from-to)71-82
Number of pages12
JournalJournal of Laboratory and Clinical Medicine
Volume142
Issue number2
DOIs
StatePublished - Aug 1 2003

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Hyperaldosteronism
Aldosterone
Epithelial Cells
Pressure regulation
Tissue
Cerebrospinal fluid
Pseudotumor Cerebri
Sweat Glands
Mineralocorticoids
Choroid Plexus
Blood pressure
Salivary Glands
Cerebrospinal Fluid
Blood Cells
Colon
Repair
Blood
Steroids
Association reactions
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Aldosteronism revisited : Perspectives on less well-recognized actions of aldosterone. / Weber, Karl.

In: Journal of Laboratory and Clinical Medicine, Vol. 142, No. 2, 01.08.2003, p. 71-82.

Research output: Contribution to journalReview article

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AB - Aldosterone is a mineralocorticoid with protean actions in both epithelial and nonepithelial cells. These include endocrine properties of circulating aldosterone that promote Na+ resorption at the expense of well-recognized K+ excretion and less well-recognized Mg 2+ excretion in classic target tissues: kidneys, colon, and sweat and salivary glands. The regulation of adrenal aldosterone secretion by [Mg 2+]o is also less well appreciated. More recently recognized endocrine actions of aldosterone include induction of Mg 2+ efflux in exchange for Na+ in such nonepithelial cells as peripheral-blood mononuclear cells and influence on epithelial cells of the choroid plexus, where aldosterone alters the composition of cerebrospinal fluid that contributes to blood-pressure regulation. An association between primary aldosteronism and idiopathic intracranial hypertension has recently been reported. Extraadrenal steroidogenesis with de novo aldosterone production by the cardiovasculature, where its auto-/paracrine properties may contribute to tissue repair at sites of injury, has been observed. These less well-recognized actions of aldosterone have led to a revival of interest in how this steroid molecule contributes to the pathophysiology of various clinical disorders.

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