Alpha-adrenergic and serotonergic actions of oxymetazoline in the rat aorta

Liang Jing, Duane Miller, Popat N. Paul

Research output: Contribution to journalArticle

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Abstract

On the rat aorta α-adrenergic and serotonergic actions of oxymetazoline were analyzed. Some competitive, reversible blockers were used for the purpose. When compared with oxymetazoline, there was a small but significant selectivity in blockade of phenylephrine by phentolamine which did not affect the response to serotonin. Dihydroergocryptine at 3 x 10-6 M caused nearly equal competitive blockade of phenylephrine and serotonin with -log K(B) of 7.96 and 7.67, respectively, but significantly reduced the maximum response to oxymetazoline. Dihydroergocristine and dihydroergocornine also competitively blocked all three agonists without significant selectivity. Ketanserin, which was selective for serotonin, did not distinguish between agonists l-phenylephrine or oxymetazoline. Although there is a small phentolamine resistance and a nonspecific dihydroergocryptine-sensitive component of the vascular action of oxymetazoline, it is concluded that the imidazoline mainly activates vascular α-adrenoceptor.

Original languageEnglish (US)
Pages (from-to)51-58
Number of pages8
JournalPharmacology Reviews and Communications
Volume10
Issue number1
StatePublished - 1997

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Oxymetazoline
Adrenergic Agents
Aorta
Dihydroergocryptine
Phenylephrine
Serotonin
Phentolamine
Dihydroergocornine
Blood Vessels
Dihydroergocristine
Imidazolines
Ketanserin
Adrenergic Receptors

All Science Journal Classification (ASJC) codes

  • Pharmacology

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Alpha-adrenergic and serotonergic actions of oxymetazoline in the rat aorta. / Jing, Liang; Miller, Duane; Paul, Popat N.

In: Pharmacology Reviews and Communications, Vol. 10, No. 1, 1997, p. 51-58.

Research output: Contribution to journalArticle

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