Alteration in oxidative stress and c-Myc protein by administration of Acidophilus-casei dahi on DMH induced colon carcinogenesis

Arvind P.R. Sinha, Nikhlesh Singh, Raj Kumar

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Inhibitory potential of Acidophilus-casei dahi (Ac Dahi; a probiotic microorganism's fermented milk product) against DMH induced colon carcinogenesis was elucidated on the basis of alteration in oxidative stress and c-Myc protein level. Ninety rats were allocated to six groups including Normal control, DMH control, DRC-1 dahi (Normal dahi), Ac Dahi- DMH-Ac Dahi (pre initiation), Ac -Dahi (initiation) and DMH+ Ac Dahi group (post initiation). At 40 th week, rats were sacrificed and activity of antioxidative enzymes i.e. Catalase and Superoxide dismutase, detoxification enzymes i.e. glutathione -s- transferase and glutathione peroxidase were estimated in RBC lysate. The c-Myc protein level was estimated in rats' colon. The results showed significant increase in antioxidant and detoxification level in Ac Dahi fed group in comparison to DMH control group. The c-Myc level was found highest in DMH control group. Feeding of Ac dahi at post initiation phase also reduced the oxidative and c-Myc protein level.

Original languageEnglish (US)
Pages (from-to)65-72
Number of pages8
JournalCurrent Topics in Nutraceutical Research
Volume7
Issue number2
StatePublished - May 1 2009

Fingerprint

Dimenhydrinate
Proto-Oncogene Proteins c-myc
Colon
Carcinogenesis
Oxidative Stress
Cultured Milk Products
Control Groups
Probiotics
Enzymes
Glutathione Peroxidase
Glutathione Transferase
Catalase
Superoxide Dismutase
Antioxidants

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Alteration in oxidative stress and c-Myc protein by administration of Acidophilus-casei dahi on DMH induced colon carcinogenesis. / Sinha, Arvind P.R.; Singh, Nikhlesh; Kumar, Raj.

In: Current Topics in Nutraceutical Research, Vol. 7, No. 2, 01.05.2009, p. 65-72.

Research output: Contribution to journalArticle

@article{c53cb639a5d9461fbd0991df028b5db0,
title = "Alteration in oxidative stress and c-Myc protein by administration of Acidophilus-casei dahi on DMH induced colon carcinogenesis",
abstract = "Inhibitory potential of Acidophilus-casei dahi (Ac Dahi; a probiotic microorganism's fermented milk product) against DMH induced colon carcinogenesis was elucidated on the basis of alteration in oxidative stress and c-Myc protein level. Ninety rats were allocated to six groups including Normal control, DMH control, DRC-1 dahi (Normal dahi), Ac Dahi- DMH-Ac Dahi (pre initiation), Ac -Dahi (initiation) and DMH+ Ac Dahi group (post initiation). At 40 th week, rats were sacrificed and activity of antioxidative enzymes i.e. Catalase and Superoxide dismutase, detoxification enzymes i.e. glutathione -s- transferase and glutathione peroxidase were estimated in RBC lysate. The c-Myc protein level was estimated in rats' colon. The results showed significant increase in antioxidant and detoxification level in Ac Dahi fed group in comparison to DMH control group. The c-Myc level was found highest in DMH control group. Feeding of Ac dahi at post initiation phase also reduced the oxidative and c-Myc protein level.",
author = "Sinha, {Arvind P.R.} and Nikhlesh Singh and Raj Kumar",
year = "2009",
month = "5",
day = "1",
language = "English (US)",
volume = "7",
pages = "65--72",
journal = "Current Topics in Nutraceutical Research",
issn = "1540-7535",
publisher = "New Century Health Publishers",
number = "2",

}

TY - JOUR

T1 - Alteration in oxidative stress and c-Myc protein by administration of Acidophilus-casei dahi on DMH induced colon carcinogenesis

AU - Sinha, Arvind P.R.

AU - Singh, Nikhlesh

AU - Kumar, Raj

PY - 2009/5/1

Y1 - 2009/5/1

N2 - Inhibitory potential of Acidophilus-casei dahi (Ac Dahi; a probiotic microorganism's fermented milk product) against DMH induced colon carcinogenesis was elucidated on the basis of alteration in oxidative stress and c-Myc protein level. Ninety rats were allocated to six groups including Normal control, DMH control, DRC-1 dahi (Normal dahi), Ac Dahi- DMH-Ac Dahi (pre initiation), Ac -Dahi (initiation) and DMH+ Ac Dahi group (post initiation). At 40 th week, rats were sacrificed and activity of antioxidative enzymes i.e. Catalase and Superoxide dismutase, detoxification enzymes i.e. glutathione -s- transferase and glutathione peroxidase were estimated in RBC lysate. The c-Myc protein level was estimated in rats' colon. The results showed significant increase in antioxidant and detoxification level in Ac Dahi fed group in comparison to DMH control group. The c-Myc level was found highest in DMH control group. Feeding of Ac dahi at post initiation phase also reduced the oxidative and c-Myc protein level.

AB - Inhibitory potential of Acidophilus-casei dahi (Ac Dahi; a probiotic microorganism's fermented milk product) against DMH induced colon carcinogenesis was elucidated on the basis of alteration in oxidative stress and c-Myc protein level. Ninety rats were allocated to six groups including Normal control, DMH control, DRC-1 dahi (Normal dahi), Ac Dahi- DMH-Ac Dahi (pre initiation), Ac -Dahi (initiation) and DMH+ Ac Dahi group (post initiation). At 40 th week, rats were sacrificed and activity of antioxidative enzymes i.e. Catalase and Superoxide dismutase, detoxification enzymes i.e. glutathione -s- transferase and glutathione peroxidase were estimated in RBC lysate. The c-Myc protein level was estimated in rats' colon. The results showed significant increase in antioxidant and detoxification level in Ac Dahi fed group in comparison to DMH control group. The c-Myc level was found highest in DMH control group. Feeding of Ac dahi at post initiation phase also reduced the oxidative and c-Myc protein level.

UR - http://www.scopus.com/inward/record.url?scp=81255190883&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81255190883&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 65

EP - 72

JO - Current Topics in Nutraceutical Research

JF - Current Topics in Nutraceutical Research

SN - 1540-7535

IS - 2

ER -