Alterations in pubertal timing following therapy for childhood malignancies

Gregory Armstrong, Eric J. Chow, Charles A. Sklar

Research output: Chapter in Book/Report/Conference proceedingChapter

26 Citations (Scopus)

Abstract

The onset of puberty marks a time of rapid linear growth, sexual development, and transition from childhood to maturity. The diagnosis and treatment of a childhood malignancy prior to the onset of puberty has the potential to profoundly affect the timing and the tempo of puberty. CNS tumors located in the hypothalamic-pituitary (H-P) region, surgical resection in this location, and exposure to CNS radiotherapy are all associated with both precocious and delayed puberty. Also, chemotherapy and radiation can directly damage the gonads, which can result in absent, arrested, or delayed puberty. As a consequence of these alterations of pubertal timing, both male and female survivors of childhood cancer may be at risk of adult short-stature, decreased bone-mineral density, absent or incomplete sexual development, and ultimately, reduced rates of fertility. Appropriate and timely assessment of survivors at high risk of alterations in pubertal development will enable the identification of patients who would benefit from early medical intervention.

Original languageEnglish (US)
Title of host publicationEndocrinopathy after Childhood Cancer Treatment
EditorsHamish Wallace, Christopher Kelnar
Pages25-39
Number of pages15
DOIs
StatePublished - Aug 10 2009

Publication series

NameEndocrine Development
Volume15
ISSN (Print)1421-7082
ISSN (Electronic)1662-2979

Fingerprint

Puberty
Delayed Puberty
Sexual Development
Survivors
Early Medical Intervention
Precocious Puberty
Neoplasms
Birth Rate
Gonads
Growth and Development
Bone Density
Radiotherapy
Therapeutics
Radiation
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems

Cite this

Armstrong, G., Chow, E. J., & Sklar, C. A. (2009). Alterations in pubertal timing following therapy for childhood malignancies. In H. Wallace, & C. Kelnar (Eds.), Endocrinopathy after Childhood Cancer Treatment (pp. 25-39). (Endocrine Development; Vol. 15). https://doi.org/10.1159/000207616

Alterations in pubertal timing following therapy for childhood malignancies. / Armstrong, Gregory; Chow, Eric J.; Sklar, Charles A.

Endocrinopathy after Childhood Cancer Treatment. ed. / Hamish Wallace; Christopher Kelnar. 2009. p. 25-39 (Endocrine Development; Vol. 15).

Research output: Chapter in Book/Report/Conference proceedingChapter

Armstrong, G, Chow, EJ & Sklar, CA 2009, Alterations in pubertal timing following therapy for childhood malignancies. in H Wallace & C Kelnar (eds), Endocrinopathy after Childhood Cancer Treatment. Endocrine Development, vol. 15, pp. 25-39. https://doi.org/10.1159/000207616
Armstrong G, Chow EJ, Sklar CA. Alterations in pubertal timing following therapy for childhood malignancies. In Wallace H, Kelnar C, editors, Endocrinopathy after Childhood Cancer Treatment. 2009. p. 25-39. (Endocrine Development). https://doi.org/10.1159/000207616
Armstrong, Gregory ; Chow, Eric J. ; Sklar, Charles A. / Alterations in pubertal timing following therapy for childhood malignancies. Endocrinopathy after Childhood Cancer Treatment. editor / Hamish Wallace ; Christopher Kelnar. 2009. pp. 25-39 (Endocrine Development).
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