Alterations Of Serum And Urinary Carnitine Profiles In Cancer Patients

Hypothesis Of Possible Significance

Wanda L. Dodson, Dileep S. Sachan, Stephen Krauss, Wahid Hanna

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The present study examined the serum and urinary carnitine concentrations of 21 cancer patients with metastatic disease and 13 healthy age-matched controls by taking three consecutive samples during an 8-week period. The serum concentrations of all fractions of carnitine were significantly lower in the female cancer patients than in the female controls. The concentrations of urinary carnitine fractions were relatively higher in the total cancer population; however, only acid-insoluble acylcarnitine (AIAC) was statistically significant. The renal clearance of acid-soluble acylcarnitine (ASAC) and AIAC was significantly greater in cancer subjects than in controls. Significant inverse relationships were established between the ASAC and AIAC clearances and their respective serum concentrations. The renal tubular reabsorption of AIAC was significantly less in cancer patients than in control subjects as indicated by the fractional excretion of carnitine. The increased clearance of acylcarnitine and excretion of large amounts of AIAC are proposed to be a response to chemotherapy and represent a loss of energy to the cancer patient.

Original languageEnglish (US)
Pages (from-to)133-142
Number of pages10
JournalJournal of the American College of Nutrition
Volume8
Issue number2
DOIs
StatePublished - Apr 1 1989
Externally publishedYes

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Carnitine
Acids
Serum
Neoplasms
acylcarnitine
Kidney
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Alterations Of Serum And Urinary Carnitine Profiles In Cancer Patients : Hypothesis Of Possible Significance. / Dodson, Wanda L.; Sachan, Dileep S.; Krauss, Stephen; Hanna, Wahid.

In: Journal of the American College of Nutrition, Vol. 8, No. 2, 01.04.1989, p. 133-142.

Research output: Contribution to journalArticle

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