Altered cross-frequency coupling in resting-state MEG after mild traumatic brain injury

Marios Antonakakis, Stavros I. Dimitriadis, Michalis Zervakis, Sifis Micheloyannis, Roozbeh Rezaie, Abbas Babajani-Feremi, George Zouridakis, Andrew Papanicolaou

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Cross-frequency coupling (CFC) is thought to represent a basic mechanism of functional integration of neural networks across distant brain regions. In this study, we analyzed CFC profiles from resting state Magnetoencephalographic (MEG) recordings obtained from 30 mild traumatic brain injury (mTBI) patients and 50 controls. We used mutual information (MI) to quantify the phase-to-amplitude coupling (PAC) of activity among the recording sensors in six nonoverlapping frequency bands. After forming the CFC-based functional connectivity graphs, we employed a tensor representation and tensor subspace analysis to identify the optimal set of features for subject classification as mTBI or control. Our results showed that controls formed a dense network of stronger local and global connections indicating higher functional integration compared to mTBI patients. Furthermore, mTBI patients could be separated from controls with more than 90% classification accuracy. These findings indicate that analysis of brain networks computed from resting-state MEG with PAC and tensorial representation of connectivity profiles may provide a valuable biomarker for the diagnosis of mTBI.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalInternational Journal of Psychophysiology
Volume102
DOIs
StatePublished - Apr 1 2016

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Brain Concussion
Brain
Biomarkers

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Physiology (medical)

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Altered cross-frequency coupling in resting-state MEG after mild traumatic brain injury. / Antonakakis, Marios; Dimitriadis, Stavros I.; Zervakis, Michalis; Micheloyannis, Sifis; Rezaie, Roozbeh; Babajani-Feremi, Abbas; Zouridakis, George; Papanicolaou, Andrew.

In: International Journal of Psychophysiology, Vol. 102, 01.04.2016, p. 1-11.

Research output: Contribution to journalArticle

Antonakakis, Marios ; Dimitriadis, Stavros I. ; Zervakis, Michalis ; Micheloyannis, Sifis ; Rezaie, Roozbeh ; Babajani-Feremi, Abbas ; Zouridakis, George ; Papanicolaou, Andrew. / Altered cross-frequency coupling in resting-state MEG after mild traumatic brain injury. In: International Journal of Psychophysiology. 2016 ; Vol. 102. pp. 1-11.
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